WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H130543
CAS#: FM04
Description: FM04 is a novel potent P-glycoprotein (P-gp) inhibitor (EC50 = 83 nM). It interacts with Q1193 and I1115 in the nucleotide-binding domain 2 (NBD2) of human P-gp, which disrupts the R262-Q1081-Q1118 interaction pocket and uncoupling ICL2-NBD2 interaction, thus inhibiting P-gp.
Hodoodo Cat#: H130543
Name: FM04
CAS#: FM04
Chemical Formula: C26H25NO4
Exact Mass: 415.18
Molecular Weight: 415.490
Elemental Analysis: C, 75.16; H, 6.07; N, 3.37; O, 15.40
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Synonym: FM-04, FM 04
IUPAC/Chemical Name: 2-(4-(2-(2-(Benzylamino)ethoxy)ethoxy)phenyl)-4H-chromen-4-one
InChi Key: JIFJFNBTQSCGBM-UHFFFAOYSA-N
InChi Code: InChI=1S/C26H25NO4/c28-24-18-26(31-25-9-5-4-8-23(24)25)21-10-12-22(13-11-21)30-17-16-29-15-14-27-19-20-6-2-1-3-7-20/h1-13,18,27H,14-17,19H2
SMILES Code: O=C1C=C(C2=CC=C(OCCOCCNCC3=CC=CC=C3)C=C2)OC4=C1C=CC=C4
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 415.49 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1. Liu Z, Wong ILK, Sang J, Liu F, Yan CSW, Kan JWY, Chan TH, Chow LMC. Identification of Binding Sites in the Nucleotide-Binding Domain of P-Glycoprotein for a Potent and Nontoxic Modulator, the Amine-Containing Monomeric Flavonoid FM04. J Med Chem. 2023 May 11;66(9):6160-6183. doi: 10.1021/acs.jmedchem.2c02005. Epub 2023 Apr 25. PMID: 37098275.
2. Kan JWY, Yan CSW, Wong ILK, Su X, Liu Z, Chan TH, Chow LMC. Discovery of a Flavonoid FM04 as a Potent Inhibitor to Reverse P-Glycoprotein-Mediated Drug Resistance in Xenografts and Improve Oral Bioavailability of Paclitaxel. Int J Mol Sci. 2022 Dec 4;23(23):15299. doi: 10.3390/ijms232315299. PMID: 36499627; PMCID: PMC9739180.