GIF-0726-r

    WARNING: This product is for research use only, not for human or veterinary use.

Hodoodo CAT#: H130550

CAS#: 302818-73-1

Description: GIF-0726-r is a novel suppressor of reactive oxygen species (ROS) accumulation. In preclinical trials, it was shown to protect mouse hippocampal cell line HT22 against oxytosis/ferroptosis.

Chemical Structure

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GIF-0726-r
CAS# 302818-73-1
Instruction

Theoretical Analysis

Hodoodo Cat#: H130550
Name: GIF-0726-r
CAS#: 302818-73-1
Chemical Formula: C17H18N2O
Exact Mass: 266.14
Molecular Weight: 266.340
Elemental Analysis: C, 76.66; H, 6.81; N, 10.52; O, 6.01

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @hodoodo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: GIF 0726 r, GIF-0726 r, GIF 0726-r, GIF-0726r, GIF 0726 r, GIF0726r

IUPAC/Chemical Name: 3-(4-(Dimethylamino)benzyl)indolin-2-one

InChi Key: WEKJKJMTUWIENI-UHFFFAOYSA-N

InChi Code: InChI=1S/C17H18N2O/c1-19(2)13-9-7-12(8-10-13)11-15-14-5-3-4-6-16(14)18-17(15)20/h3-10,15H,11H2,1-2H3,(H,18,20)

SMILES Code: O=C1NC2=C(C=CC=C2)C1CC3=CC=C(N(C)C)C=C3

Appearance: To be determined

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 266.34 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1. Takahashi M, Hamamoto A, Oh-Hashi K, Takemori H, Furuta K, Hirata Y. Antiferroptotic Activities of Oxindole GIF-0726-r Derivatives: Involvement of Ferrous Iron Coordination and Free-Radical Scavenging Capacities. ACS Chem Neurosci. 2023 May 17;14(10):1826-1833. doi: 10.1021/acschemneuro.3c00042. Epub 2023 Apr 27. PMID: 37104649.

2. Hasegawa Y, Motoyama M, Hamamoto A, Kimura S, Kamatari YO, Kamishina H, Oh-Hashi K, Furuta K, Hirata Y. Identification of Novel Oxindole Compounds That Suppress ER Stress-Induced Cell Death as Chemical Chaperones. ACS Chem Neurosci. 2022 Apr 6;13(7):1055-1064. doi: 10.1021/acschemneuro.2c00064. Epub 2022 Mar 16. PMID: 35294164.

3. Hirata Y, Tsunekawa Y, Takahashi M, Oh-Hashi K, Kawaguchi K, Hayazaki M, Watanabe M, Koga KI, Hattori Y, Takemori H, Furuta K. Identification of novel neuroprotective N,N-dimethylaniline derivatives that prevent oxytosis/ferroptosis and localize to late endosomes and lysosomes. Free Radic Biol Med. 2021 Oct;174:225-235. doi: 10.1016/j.freeradbiomed.2021.08.015. Epub 2021 Aug 15. PMID: 34407426.

4. Hirata Y, Ito Y, Takashima M, Yagyu K, Oh-Hashi K, Suzuki H, Ono K, Furuta K, Sawada M. Novel Oxindole-Curcumin Hybrid Compound for Antioxidative Stress and Neuroprotection. ACS Chem Neurosci. 2020 Jan 2;11(1):76-85. doi: 10.1021/acschemneuro.9b00619. Epub 2019 Dec 18. PMID: 31799835.

5. Hirata Y, Yamada C, Ito Y, Yamamoto S, Nagase H, Oh-Hashi K, Kiuchi K, Suzuki H, Sawada M, Furuta K. Novel oxindole derivatives prevent oxidative stress-induced cell death in mouse hippocampal HT22 cells. Neuropharmacology. 2018 Jun;135:242-252. doi: 10.1016/j.neuropharm.2018.03.015. Epub 2018 Mar 15. PMID: 29551691.