WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H130533
CAS#: MMV008416
Description: MMV008416 is an inhibitor of methionine aminopeptidases, type I (MetAp1) from Rickettsia prowazekii (RpMetAp1).
Hodoodo Cat#: H130533
Name: MMV008416
CAS#: MMV008416
Chemical Formula: C15H20N2
Exact Mass: 228.16
Molecular Weight: 228.340
Elemental Analysis: C, 78.90; H, 8.83; N, 12.27
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Synonym: MMV 008416, MMV-008416, GNF-Pf-3651, MLS000080101, SMR000036351, NSC766427, STK007737, AKOS005375852, NSC-766427
IUPAC/Chemical Name: 3-Ethyl-1-methyl-2-propylquinolin-4-imine
InChi Key: JAPBALWUJAIERZ-UHFFFAOYSA-N
InChi Code: InChI=1S/C15H20N2/c1-4-8-13-11(5-2)15(16)12-9-6-7-10-14(12)17(13)3/h6-7,9-10,16H,4-5,8H2,1-3H3
SMILES Code: CCC1=C(CCC)N(C)C2=CC=CC=C2C1=N
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 228.34 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1. Sharma I, Chen C, Daraji D, Horn JR, Hagen TJ. Novel inhibitors of Rickettsia prowazekii methionine aminopeptidase from the Malaria Box. Bioorg Med Chem Lett. 2023 May 1;87:129281. doi: 10.1016/j.bmcl.2023.129281. Epub 2023 Apr 7. PMID: 37031729.
2. Chirawurah JD, Ansah F, Nyarko PB, Duodu S, Aniweh Y, Awandare GA. Antimalarial activity of Malaria Box Compounds against Plasmodium falciparum clinical isolates. Int J Parasitol Drugs Drug Resist. 2017 Dec;7(3):399-406. doi: 10.1016/j.ijpddr.2017.10.005. Epub 2017 Oct 16. PMID: 29128848; PMCID: PMC5683671.
3. Meister S, Plouffe DM, Kuhen KL, Bonamy GM, Wu T, Barnes SW, Bopp SE, Borboa R, Bright AT, Che J, Cohen S, Dharia NV, Gagaring K, Gettayacamin M, Gordon P, Groessl T, Kato N, Lee MC, McNamara CW, Fidock DA, Nagle A, Nam TG, Richmond W, Roland J, Rottmann M, Zhou B, Froissard P, Glynne RJ, Mazier D, Sattabongkot J, Schultz PG, Tuntland T, Walker JR, Zhou Y, Chatterjee A, Diagana TT, Winzeler EA. Imaging of Plasmodium liver stages to drive next-generation antimalarial drug discovery. Science. 2011 Dec 9;334(6061):1372-7. doi: 10.1126/science.1211936. Epub 2011 Nov 17. PMID: 22096101; PMCID: PMC3473092.