WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H130573
CAS#: 2797183-37-8
Description: NSD2-PWWP1 inhibitor 38 is a novel, potent, and selective NSD2-PWWP1 inhibitor. It binds to NSD2-PWWP1 and affects the expression of NSD2-regulated genes.
Hodoodo Cat#: H130573
Name: NSD2-PWWP1 inhibitor 38
CAS#: 2797183-37-8
Chemical Formula: C29H31N5
Exact Mass: 449.26
Molecular Weight: 449.600
Elemental Analysis: C, 77.47; H, 6.95; N, 15.58
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Synonym: NSD2-PWWP1-inhibitor-38, NSD2 PWWP1 inhibitor 38, NSD2 PWWP1 In 38, NSD2 PWWP1-In 38, NSD2 PWWP1-In-38, NSD2-PWWP1-In-38
IUPAC/Chemical Name: 4-(4-(4-((4-Aminopiperidin-1-yl)methyl)-2,6-dimethylphenyl)-1-methyl-1H-imidazol-5-yl)-1-naphthonitrile
InChi Key: YELBNEVEPNGEGQ-UHFFFAOYSA-N
InChi Code: InChI=1S/C29H31N5/c1-19-14-21(17-34-12-10-23(31)11-13-34)15-20(2)27(19)28-29(33(3)18-32-28)26-9-8-22(16-30)24-6-4-5-7-25(24)26/h4-9,14-15,18,23H,10-13,17,31H2,1-3H3
SMILES Code: N#CC1=C2C=CC=CC2=C(C3=C(C4=C(C)C=C(CN5CCC(N)CC5)C=C4C)N=CN3C)C=C1
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 449.60 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1. Li N, Yang H, Liu K, Zhou L, Huang Y, Cao D, Li Y, Sun Y, Yu A, Du Z, Yu F, Zhang Y, Wang B, Geng M, Li J, Xiong B, Xu S, Huang X, Liu T. Structure-Based Discovery of a Series of NSD2-PWWP1 Inhibitors. J Med Chem. 2022 Jul 14;65(13):9459-9477. doi: 10.1021/acs.jmedchem.2c00709. Epub 2022 Jun 15. PMID: 35704853.