WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H207195
CAS#: Unknown
Description: PF-07284892 is a small molecule inhibitor of protein tyrosine phosphatase (PTP) non-receptor type 11 (SHP2; Src homology region 2 domain phosphatase; PTPN11), with potential antineoplastic activity. Upon administration, PF-07284892 targets, binds to and inhibits the activity of SHP2. This prevents SHP2-mediated signaling, inhibits MAPK signaling and prevents growth of SHP2-expressing tumor cells. SHP2, an oncoprotein overexpressed in a variety of cancer cell types, regulates cell survival, differentiation and proliferation through activation of the Ras-Raf-MEK-ERK signaling pathway.
Hodoodo Cat#: H207195
Name: PF-07284892
CAS#: Unknown
Chemical Formula: C22H23ClN6S
Exact Mass: 438.14
Molecular Weight: 438.978
Elemental Analysis: C, 60.19; H, 5.28; Cl, 8.08; N, 19.14; S, 7.30
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Related CAS #: 2414482-07-6 (cyano)
Synonym: PF-07284892; PF 07284892; PF07284892;
IUPAC/Chemical Name: (S)-1'-(6-((3-amino-2-chlorophenyl)thio)-1,2,4-triazin-3-yl)-1,3-dihydrospiro[indene-2,4'-piperidin]-1-amine
InChi Key: VWHIFLPCODGQHW-HXUWFJFHSA-N
InChi Code: InChI=1S/C22H23ClN6S/c23-19-16(24)6-3-7-17(19)30-18-13-26-21(28-27-18)29-10-8-22(9-11-29)12-14-4-1-2-5-15(14)20(22)25/h1-7,13,20H,8-12,24-25H2/t20-/m1/s1
SMILES Code: N[C@H]1C2(CCN(C3=NC=C(SC4=CC=CC(N)=C4Cl)N=N3)CC2)CC5=C1C=CC=C5
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info: The Ras-MAPK pathway is often hyperactivated in cancer cells due to specific mutations and rearrangements, and are dependent on SHP2 for their oncogenic signaling. SHP2 also regulates programmed cell death 1 (PD-1)-mediated signal transduction and is involved in immune checkpoint modulation.
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The following data is based on the product molecular weight 438.98 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
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