WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H130577
CAS#: Tubulin Inhibitor 3a
Description: Tubulin Inhibitor 3a is a novel colchicine-binding site tubulin inhibitor with immune-potentiating and antitumor effects against melanoma.
Hodoodo Cat#: H130577
Name: Tubulin Inhibitor 3a
CAS#: Tubulin Inhibitor 3a
Chemical Formula: C24H22N4O3
Exact Mass: 414.17
Molecular Weight: 414.470
Elemental Analysis: C, 69.55; H, 5.35; N, 13.52; O, 11.58
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Synonym: Tubulin In 3a, Tubulin-In-3a, Tubulin Inhibitor-3a, Tubulin-Inhibitor-3a
IUPAC/Chemical Name: 2-(1-Methyl-1H-indol-4-yl)-4-(3,4,5-trimethoxyphenyl)-1H-imidazo[4,5-c]pyridine
InChi Key: MWCSERIKIAEYNW-UHFFFAOYSA-N
InChi Code: InChI=1S/C23H19N4O3/c1-28-18-11-13(12-19(29-2)22(18)30-3)20-21-17(8-10-25-20)26-23(27-21)15-5-4-6-16-14(15)7-9-24-16/h4-12H,1-3H3,(H,26,27)
SMILES Code: COC1=C(OC)C(OC)=CC(C2=NC=CC3=C2N=C(C4=CC=CC5=C4C=C[N]5)N3)=C1
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 414.47 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1. Ren Y, Wang Y, Liu J, Liu T, Yuan L, Wu C, Yang Z, Chen J. X-ray Crystal Structure-Guided Discovery of Novel Indole Analogues as Colchicine-Binding Site Tubulin Inhibitors with Immune-Potentiating and Antitumor Effects against Melanoma. J Med Chem. 2023 May 25;66(10):6697-6714. doi: 10.1021/acs.jmedchem.3c00011. Epub 2023 May 5. PMID: 37145846.