TYK2-IN-47

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Hodoodo CAT#: H130536

CAS#: TYK2-IN-47

Description: TYK2-IN-47 is a novel, highly selective allosteric inhibitor of tyrosine kinase 2 (TYK2).

Chemical Structure

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TYK2-IN-47
CAS# TYK2-IN-47
Instruction

Theoretical Analysis

Hodoodo Cat#: H130536
Name: TYK2-IN-47
CAS#: TYK2-IN-47
Chemical Formula: C17H16D3N5O4S
Exact Mass: 392.13
Molecular Weight: 392.450
Elemental Analysis: C, 52.03; H, 5.65; N, 17.85; O, 16.31; S, 8.17

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @hodoodo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: TYK2 In 47, TYK2 In-47, TYK2-In 47, TYK2 Inhibitor 47, TYK2 Inhibitor-47, TYK2-Inhibitor 47

IUPAC/Chemical Name: 6-(Cyclopropanecarboxamido)-N-(methyl-d3)-4-((2-(methylsulfonyl)phenyl)amino)pyridazine-3-carboxamide

InChi Key: NAQXRHXESYEFJR-FIBGUPNXSA-N

InChi Code: InChI=1S/C17H19N5O4S/c1-18-17(24)15-12(9-14(21-22-15)20-16(23)10-7-8-10)19-11-5-3-4-6-13(11)27(2,25)26/h3-6,9-10H,7-8H2,1-2H3,(H,18,24)(H2,19,20,21,23)/i1D3

SMILES Code: O=C(C1=NN=C(NC(C2CC2)=O)C=C1NC3=CC=CC=C3S(=O)(C)=O)NC([2H])([2H])[2H]

Appearance: To be determined

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 392.45 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1. Moslin R, Zhang Y, Wrobleski ST, Lin S, Mertzman M, Spergel S, Tokarski JS, Strnad J, Gillooly K, McIntyre KW, Zupa-Fernandez A, Cheng L, Sun H, Chaudhry C, Huang C, D'Arienzo C, Heimrich E, Yang X, Muckelbauer JK, Chang C, Tredup J, Mulligan D, Xie D, Aranibar N, Chiney M, Burke JR, Lombardo L, Carter PH, Weinstein DS. Identification of N-Methyl Nicotinamide and N-Methyl Pyridazine-3-Carboxamide Pseudokinase Domain Ligands as Highly Selective Allosteric Inhibitors of Tyrosine Kinase 2 (TYK2). J Med Chem. 2019 Oct 24;62(20):8953-8972. doi: 10.1021/acs.jmedchem.9b00443. Epub 2019 Jul 17. PMID: 31314518.