UNC-YL-206

    WARNING: This product is for research use only, not for human or veterinary use.

Hodoodo CAT#: H130530

CAS#: UNC-YL-206

Description: UNC-YL-206 is a novel potent and selective CDKL5/GSK3 probe with neuroprotective activity.

Chemical Structure

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UNC-YL-206
CAS# UNC-YL-206
Instruction

Theoretical Analysis

Hodoodo Cat#: H130530
Name: UNC-YL-206
CAS#: UNC-YL-206
Chemical Formula: C16H17F2N5O2
Exact Mass: 349.14
Molecular Weight: 349.340
Elemental Analysis: C, 55.01; H, 4.91; F, 10.88; N, 20.05; O, 9.16

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @hodoodo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: UNC YL 206, UNC YL-206, CDKL5/GSK3 probe 2, CDKL5/GSK3 probe-2, CDKL5/GSK3-2, CDKL5/GSK3 2

IUPAC/Chemical Name: 4-(2,6-Difluorobenzamido)-N-(piperidin-4-yl)-1H-pyrazole-5-carboxamide

InChi Key: CXBHMSHVCKEEGW-UHFFFAOYSA-N

InChi Code: InChI=1S/C16H17F2N5O2/c17-10-2-1-3-11(18)13(10)15(24)22-12-8-20-23-14(12)16(25)21-9-4-6-19-7-5-9/h1-3,8-9,19H,4-7H2,(H,20,23)(H,21,25)(H,22,24)

SMILES Code: O=C(C1=C(NC(C2=C(F)C=CC=C2F)=O)C=NN1)NC3CCNCC3

Appearance: To be determined

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 349.34 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1. Ong HW, Liang Y, Richardson W, Lowry ER, Wells CI, Chen X, Silvestre M, Dempster K, Silvaroli JA, Smith JL, Wichterle H, Pabla NS, Ultanir SK, Bullock AN, Drewry DH, Axtman AD. Discovery of a Potent and Selective CDKL5/GSK3 Chemical Probe That Is Neuroprotective. ACS Chem Neurosci. 2023 May 3;14(9):1672-1685. doi: 10.1021/acschemneuro.3c00135. Epub 2023 Apr 21. PMID: 37084253; PMCID: PMC10161233.

2. Ong HW, Liang Y, Richardson W, Lowry ER, Wells CI, Chen X, Silvestre M, Dempster K, Silvaroli JA, Smith JL, Wichterle H, Pabla NS, Ultanir SK, Bullock AN, Drewry DH, Axtman AD. A Potent and Selective CDKL5/GSK3 Chemical Probe is Neuroprotective. bioRxiv [Preprint]. 2023 Feb 10:2023.02.09.527935. doi: 10.1101/2023.02.09.527935. Update in: ACS Chem Neurosci. 2023 Apr 21;: PMID: 36798313; PMCID: PMC9934649.