WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H130584
CAS#: AhR agonist III11
Description: AhR agonist III11 is a novel, potent AhR agonist. It enhances the expression of AhR downstream target genes, triggering AhR nuclear translocation, and promoting differentiation of regulatory T cells. It exhibits good bioavailability (F = 87.40%) and strong therapeutic effects in a mouse model of ulcerative colitis at a dosage of 10 mg/kg
Hodoodo Cat#: H130584
Name: AhR agonist III11
CAS#: AhR agonist III11
Chemical Formula: C17H17NO2
Exact Mass: 267.13
Molecular Weight: 267.330
Elemental Analysis: C, 76.38; H, 6.41; N, 5.24; O, 11.97
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Synonym: AhR agonist-III11, AhR-agonist-III11, AhR Ag III11, AhR Ag-III11, AhR-Ag-III11
IUPAC/Chemical Name: 2-Methoxy-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-9-ol
InChi Key: USMDAGDIOLYERI-INIZCTEOSA-N
InChi Code: InChI=1S/C17H17NO2/c1-20-13-7-10-4-5-18-16-8-11-6-12(19)2-3-14(11)15(9-13)17(10)16/h2-3,6-7,9,16,18-19H,4-5,8H2,1H3/t16-/m0/s1
SMILES Code: OC1=CC=C2C3=C4C(CCN[C@H]4CC2=C1)=CC(OC)=C3
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 267.33 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1. Lin L, Liu Y, Chen L, Dai Y, Xia Y. Discovery of Norisoboldine Analogue III11 as a Novel and Potent Aryl Hydrocarbon Receptor Agonist for the Treatment of Ulcerative Colitis. J Med Chem. 2023 May 25;66(10):6869-6888. doi: 10.1021/acs.jmedchem.3c00287. Epub 2023 May 8. PMID: 37154394.