WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H130604
CAS#: DBt-10
Description: DBt-10 is a novel, potent, and selective DCAF1-BTK PROTAC.
Hodoodo Cat#: H130604
Name: DBt-10
CAS#: DBt-10
Chemical Formula: C68H86ClFN16O6
Exact Mass: 1,276.66
Molecular Weight: 1,277.990
Elemental Analysis: C, 63.91; H, 6.78; Cl, 2.77; F, 1.49; N, 17.54; O, 7.51
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Synonym: DBt 10, DBt10
IUPAC/Chemical Name: N-(3-(6-(1-(2-(4-(2-(5-(4-(4-((2-Aminoethyl)amino)-2-(1-(4-chlorophenyl)cyclohexyl)quinazolin-7-yl)piperazin-1-yl)-5-oxopentanamido)ethyl)-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl)-2-oxoethyl)-1H-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-5-fluoro-2-methylphenyl)-3-hydroxy-3-neopentylazetidine-1-carboxamide
InChi Key: LBIYUFWGBHNKTG-UHFFFAOYSA-N
InChi Code: InChI=1S/C68H86ClFN16O6/c1-45-52(33-49(70)34-54(45)79-64(90)85-41-66(91,42-85)40-65(2,3)4)60-53-36-55(77-62(53)75-44-74-60)46-37-76-86(38-46)39-59(89)83-24-19-67(20-25-83)43-81(31-32-92-67)26-23-72-57(87)9-8-10-58(88)84-29-27-82(28-30-84)50-15-16-51-56(35-50)78-63(80-61(51)73-22-21-71)68(17-6-5-7-18-68)47-11-13-48(69)14-12-47/h11-16,33-38,44,91H,5-10,17-32,39-43,71H2,1-4H3,(H,72,87)(H,79,90)(H,73,78,80)(H,74,75,77)
SMILES Code: O=C(N1CC(CC(C)(C)C)(O)C1)NC2=CC(F)=CC(C3=C4C(NC(C5=CN(CC(N(CC6)CCC76CN(CCNC(CCCC(N8CCN(C9=CC%10=NC(C%11(C%12=CC=C(Cl)C=C%12)CCCCC%11)=NC(NCCN)=C%10C=C9)CC8)=O)=O)CCO7)=O)N=C5)=C4)=NC=N3)=C2C
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 1,277.99 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1. Zhou Y, Kuang G, Li J, Halldin C, Nordberg A, Långström B, Tu Y, Ågren H. In silico studies of ASEM analogues targeting α7-nAChR and experimental verification. RSC Adv. 2021 Jan 21;11(7):3942-3951. doi: 10.1039/d0ra10435c. PMID: 35747361; PMCID: PMC9134020.
2. Teodoro R, Scheunemann M, Deuther-Conrad W, Wenzel B, Fasoli FM, Gotti C, Kranz M, Donat CK, Patt M, Hillmer A, Zheng MQ, Peters D, Steinbach J, Sabri O, Huang Y, Brust P. A Promising PET Tracer for Imaging of α₇ Nicotinic Acetylcholine Receptors in the Brain: Design, Synthesis, and in Vivo Evaluation of a Dibenzothiophene-Based Radioligand. Molecules. 2015 Oct 9;20(10):18387-421. doi: 10.3390/molecules201018387. PMID: 26473809; PMCID: PMC6332508.
3. Hillmer AT, Zheng MQ, Li S, Scheunemann M, Lin SF, Holden D, Labaree D, Ropchan J, Teodoro R, Deuther-Conrad W, Carson RE, Brust P, Huang Y. PET imaging evaluation of [(18)F]DBT-10, a novel radioligand specific to α7 nicotinic acetylcholine receptors, in nonhuman primates. Eur J Nucl Med Mol Imaging. 2016 Mar;43(3):537-47. doi: 10.1007/s00259-015-3209-0. Epub 2015 Oct 12. PMID: 26455500; PMCID: PMC4733418.