KAT8 inhibitor 34

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Hodoodo CAT#: H130590

CAS#: KAT8 inhibitor 34

Description: KAT8 inhibitor 34 is a novel selective inhibitor of the lysine acetyltransferase KAT8.

Chemical Structure

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KAT8 inhibitor 34
CAS# KAT8 inhibitor 34
Instruction

Theoretical Analysis

Hodoodo Cat#: H130590
Name: KAT8 inhibitor 34
CAS#: KAT8 inhibitor 34
Chemical Formula: C21H15N3O3
Exact Mass: 357.11
Molecular Weight: 357.370
Elemental Analysis: C, 70.58; H, 4.23; N, 11.76; O, 13.43

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @hodoodo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: KAT8 In 34, KAT8-inhibitor-34, KAT8 inhibitor-34, KAT8-In-34, KAT8 In-34, KAT8-34, KAT8 34

IUPAC/Chemical Name: (Z)-4-(4-((1H-Pyrrol-2-yl)methylene)-5-oxo-3-phenyl-4,5-dihydro-1H-pyrazol-1-yl)benzoic acid

InChi Key: XZSXRFQYJMTUKM-AQTBWJFISA-N

InChi Code: InChI=1S/C21H15N3O3/c25-20-18(13-16-7-4-12-22-16)19(14-5-2-1-3-6-14)23-24(20)17-10-8-15(9-11-17)21(26)27/h1-13,22H,(H,26,27)/b18-13-

SMILES Code: O=C(O)C1=CC=C(N2N=C(C3=CC=CC=C3)/C(C2=O)=C/C4=CC=CN4)C=C1

Appearance: To be determined

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 357.37 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1. Fiorentino F, Sementilli S, Menna M, Turrisi F, Tomassi S, Pellegrini FR, Iuzzolino A, D'Acunzo F, Feoli A, Wapenaar H, Taraglio S, Fraschetti C, Del Bufalo D, Sbardella G, Dekker FJ, Paiardini A, Trisciuoglio D, Mai A, Rotili D. First-in-Class Selective Inhibitors of the Lysine Acetyltransferase KAT8. J Med Chem. 2023 May 25;66(10):6591-6616. doi: 10.1021/acs.jmedchem.2c01937. Epub 2023 May 8. PMID: 37155735; PMCID: PMC10226132.