WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H130599
CAS#: Pep2
Description: Pep2 is a an anti-TNF-α Peptide (KD = 5.14 μM), directly binding to TNF-α and blocking TNF-α-triggered signaling activation.
Hodoodo Cat#: H130599
Name: Pep2
CAS#: Pep2
Chemical Formula: C44H65N15O11S
Exact Mass: 1,011.47
Molecular Weight: 1,012.160
Elemental Analysis: C, 52.21; H, 6.47; N, 20.76; O, 17.39; S, 3.17
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Synonym: ACHAWAPTR, Pep 2, Pep-2, Peptide Pep2, peptide Pep 2, peptide Pep-2
IUPAC/Chemical Name: Ala-Cys-His-Ala-Trp-Ala-Pro-Thr-Arg
InChi Key: XWCNNWPTHCJOSC-WLNDDOFLSA-N
InChi Code: InChI=1S/C44H65N15O11S/c1-21(45)35(61)57-32(19-71)39(65)56-31(16-26-18-48-20-51-26)38(64)52-22(2)36(62)55-30(15-25-17-50-28-10-6-5-9-27(25)28)37(63)53-23(3)42(68)59-14-8-12-33(59)40(66)58-34(24(4)60)41(67)54-29(43(69)70)11-7-13-49-44(46)47/h5-6,9-10,17-18,20-24,29-34,50,60,71H,7-8,11-16,19,45H2,1-4H3,(H,48,51)(H,52,64)(H,53,63)(H,54,67)(H,55,62)(H,56,65)(H,57,61)(H,58,66)(H,69,70)(H4,46,47,49)/t21-,22-,23-,24+,29-,30-,31-,32-,33-,34-/m0/s1
SMILES Code: O=C(N[C@@H](CS)C(N[C@@H](CC1=CNC=N1)C(N[C@@H](C)C(N[C@@H](CC2=CNC3=CC=CC=C23)C(N[C@@H](C)C(N4[C@@H](CCC4)C(N[C@@H]([C@H](O)C)C(N[C@@H](CCCNC(N)=N)C(O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](C)N
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 1,012.16 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1. Wang H, Wang J, Zhao X, Ye R, Sun L, Wang J, Li L, Liang H, Wang S, Lu Y. Discovery of an Anti-TNF-α 9-mer Peptide from a T7 Phage Display Library for the Treatment of Inflammatory Bowel Disease. J Med Chem. 2023 May 25;66(10):6981-6993. doi: 10.1021/acs.jmedchem.3c00436. Epub 2023 May 16. PMID: 37191335.