WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H130594
CAS#: TBE56
Description: TBE56 interacts and promotes the degradation of BACH1, 50-fold more potent than hemin. TBE56 degrades BACH1 in lung and breast cancer cells, impairing breast cancer cell migration and invasion in a BACH1-dependent manner.
Hodoodo Cat#: H130594
Name: TBE56
CAS#: TBE56
Chemical Formula: C36H43N5O6S
Exact Mass: 673.29
Molecular Weight: 673.830
Elemental Analysis: C, 64.17; H, 6.43; N, 10.39; O, 14.25; S, 4.76
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Synonym: TBE 56, TBE-56
IUPAC/Chemical Name: [(1R,4aS,8aS,10aR)-3,7-dicyano-8a-ethynyl-1,4a-dimethyl-2,6-dioxo-10,10a-dihydro-9H-phenanthren-1-yl]methyl 6-[4-[(3aS,4S,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]butoxyamino]hexanoate
InChi Key: YYUWIUDLRNXIDE-CUBWZREKSA-N
InChi Code: InChI=1S/C36H43N5O6S/c1-4-36-13-12-28-34(2,29(36)16-26(42)23(18-36)19-37)17-24(20-38)32(44)35(28,3)22-46-30(43)11-6-5-8-14-39-47-15-9-7-10-27-31-25(21-48-27)40-33(45)41-31/h1,16-18,25,27-28,31,39H,5-15,21-22H2,2-3H3,(H2,40,41,45)/t25-,27-,28+,31-,34-,35-,36-/m0/s1
SMILES Code: C[C@]12C=C(C(=O)[C@@]([C@@H]1CC[C@@]3(C2=CC(=O)C(=C3)C#N)C#C)(C)COC(=O)CCCCCNOCCCC[C@H]4[C@@H]5[C@H](CS4)NC(=O)N5)C#N
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 673.83 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1. Moreno R, Casares L, Higgins M, Ali KX, Honda T, Wiel C, Sayin VI, Dinkova-Kostova AT, de la Vega L. Biotinylation of an acetylenic tricyclic bis(cyanoenone) lowers its potency as an NRF2 activator while creating a novel activity against BACH1. Free Radic Biol Med. 2022 Oct;191:203-211. doi: 10.1016/j.freeradbiomed.2022.08.041. Epub 2022 Sep 6. PMID: 36084789.