WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H534941
CAS#: 115103-15-6
Description: Tribendimidine (TBD) is a broad-spectrum anthelmintic drug that is also significantly effective in treating clonorchiasis. It is a derivative of amidantel. Tribendimidine was as effective as praziquantel against O. felineus liver flukes.
Hodoodo Cat#: H534941
Name: Tribendimidine
CAS#: 115103-15-6
Chemical Formula: C28H32N6
Exact Mass: 452.27
Molecular Weight: 452.606
Elemental Analysis: C, 74.30; H, 7.13; N, 18.57
Synonym: Tribendimidine
IUPAC/Chemical Name: Ethanimidamide, N',N'''-(1,4-phenylenebis(methylidynenitrilo-4,1-phenylene))bis(N,N-dimethyl-Tribendimidine
InChi Key: XOIOGKHKNQYULW-HTNNXBMUSA-N
InChi Code: InChI=1S/C28H32N6/c1-21(33(3)4)31-27-15-11-25(12-16-27)29-19-23-7-9-24(10-8-23)20-30-26-13-17-28(18-14-26)32-22(2)34(5)6/h7-20H,1-6H3/b29-19+,30-20+,31-21+,32-22+
SMILES Code: C/C(N(C)C)=N\C1=CC=C(/N=C/C2=CC=C(/C=N/C3=CC=C(/N=C(N(C)C)\C)C=C3)C=C2)C=C1
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
| Biological target: | |
| In vitro activity: | |
| In vivo activity: |
The following data is based on the product molecular weight 452.61 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
1: Lv S, Ding W, Bergquist R, Yang G, Guo J, Zhou XN. Swiss-Chinese Cooperation in Tropical Medicine: The Role of Professor Marcel Tanner. Diseases. 2022 Oct 8;10(4):83. doi: 10.3390/diseases10040083. PMID: 36278582; PMCID: PMC9624330.
2: Qian MB, Patel C, Palmeirim MS, Wang X, Schindler C, Utzinger J, Zhou XN, Keiser J. Efficacy of drugs against clonorchiasis and opisthorchiasis: a systematic review and network meta-analysis. Lancet Microbe. 2022 Aug;3(8):e616-e624. doi: 10.1016/S2666-5247(22)00026-X. Epub 2022 Jun 10. PMID: 35697047.
3: Yufen W, Xinru L, Jian X, Huolele, Zhihua J, Yu C, Mingyong L, Haobing Z. Metabolome alterations in Clonorchis sinensis after treatment with tribendimidine and praziquante in vivo. Acta Trop. 2022 Jun;230:106330. doi: 10.1016/j.actatropica.2022.106330. Epub 2022 Jan 25. PMID: 35090859.
4: Keiser J, Häberli C. Evaluation of Commercially Available Anthelminthics in Laboratory Models of Human Intestinal Nematode Infections. ACS Infect Dis. 2021 May 14;7(5):1177-1185. doi: 10.1021/acsinfecdis.0c00719. Epub 2021 Jan 7. PMID: 33410658.
5: Brussee JM, Hiroshige N, Neodo A, Coulibaly JT, Pfister M, Keiser J. Population Pharmacokinetics and Exposure-Response Analysis of Tribendimidine To Improve Treatment for Children with Hookworm Infection. Antimicrob Agents Chemother. 2021 Jan 20;65(2):e01778-20. doi: 10.1128/AAC.01778-20. PMID: 33139293; PMCID: PMC7848977.
6: Brussee JM, Neodo A, Schulz JD, Coulibaly JT, Pfister M, Keiser J. Pharmacometric Analysis of Tribendimidine Monotherapy and Combination Therapies To Achieve High Cure Rates in Patients with Hookworm Infections. Antimicrob Agents Chemother. 2021 Jan 20;65(2):e00714-20. doi: 10.1128/AAC.00714-20. PMID: 33139276; PMCID: PMC7849000.
7: Barda B, Schindler C, Wampfler R, Ame S, Ali SM, Keiser J. Comparison of real-time PCR and the Kato-Katz method for the diagnosis of soil-transmitted helminthiasis and assessment of cure in a randomized controlled trial. BMC Microbiol. 2020 Oct 2;20(1):298. doi: 10.1186/s12866-020-01963-9. PMID: 33008301; PMCID: PMC7531123.
8: Qian MB, Zhou CH, Zhu HH, Zhu TJ, Huang JL, Chen YD, Zhou XN. From awareness to action: NIPD's engagement in the control of food-borne clonorchiasis. Adv Parasitol. 2020;110:245-267. doi: 10.1016/bs.apar.2020.04.004. Epub 2020 May 18. PMID: 32563327.
9: Zhang H, Liu C, Zheng Q. Development and application of anthelminthic drugs in China. Acta Trop. 2019 Dec;200:105181. doi: 10.1016/j.actatropica.2019.105181. Epub 2019 Sep 19. PMID: 31542370.
10: Choudhary S, Tipton JG, Abongwa M, Brewer MT, Chelladurai JJ, Musselman N, Martin RJ, Robertson AP. Pharmacological characterization of a homomeric nicotinic acetylcholine receptor formed by Ancylostoma caninum ACR-16. Invert Neurosci. 2019 Sep 5;19(4):11. doi: 10.1007/s10158-019-0231-0. PMID: 31486912; PMCID: PMC7869652.
11: Cortez-Maya S, Moreno-Herrera A, Palos I, Rivera G. Old Antiprotozoal Drugs: Are They Still Viable Options for Parasitic Infections or New Options for Other Diseases? Curr Med Chem. 2020;27(32):5403-5428. doi: 10.2174/0929867326666190628163633. PMID: 31264538.
12: Meister I, Assawasuwannakit P, Vanobberghen F, Penny MA, Odermatt P, Sayasone S, Huwyler J, Tarning J, Keiser J. Pooled Population Pharmacokinetic Analysis of Tribendimidine for the Treatment of Opisthorchis viverrini Infections. Antimicrob Agents Chemother. 2019 Mar 27;63(4):e01391-18. doi: 10.1128/AAC.01391-18. PMID: 30718244; PMCID: PMC6437521.
13: Pakharukova MY, Samsonov VA, Serbina EA, Mordvinov VA. A study of tribendimidine effects in vitro and in vivo on the liver fluke Opisthorchis felineus. Parasit Vectors. 2019 Jan 11;12(1):23. doi: 10.1186/s13071-019-3288-z. PMID: 30635027; PMCID: PMC6329057.
14: Coulibaly JT, Hiroshige N, N'Gbesso YK, Hattendorf J, Keiser J. Efficacy and Safety of Ascending Dosages of Tribendimidine Against Hookworm Infections in Children: A Randomized Controlled Trial. Clin Infect Dis. 2019 Aug 16;69(5):845-852. doi: 10.1093/cid/ciy999. PMID: 30496350.
15: Neodo A, Schulz JD, Huwyler J, Keiser J. In Vitro and In Vivo Drug-Drug Interaction Study of the Effects of Ivermectin and Oxantel Pamoate on Tribendimidine. Antimicrob Agents Chemother. 2018 Dec 21;63(1):e00762-18. doi: 10.1128/AAC.00762-18. PMID: 30323047; PMCID: PMC6325189.
16: Schneeberger PHH, Coulibaly JT, Gueuning M, Moser W, Coburn B, Frey JE, Keiser J. Off-target effects of tribendimidine, tribendimidine plus ivermectin, tribendimidine plus oxantel-pamoate, and albendazole plus oxantel-pamoate on the human gut microbiota. Int J Parasitol Drugs Drug Resist. 2018 Dec;8(3):372-378. doi: 10.1016/j.ijpddr.2018.07.001. Epub 2018 Jul 2. PMID: 30007544; PMCID: PMC6068340.
17: Hiroshige N, Coulibaly J, Huwyler J, Bonate PL, Keiser J. Pharmacokinetics of a Pediatric Tribendimidine Dose-Finding Study To Treat Hookworm Infection in African Children. Antimicrob Agents Chemother. 2018 Aug 27;62(9):e00959-18. doi: 10.1128/AAC.00959-18. PMID: 29914958; PMCID: PMC6125550.
18: Maheu-Giroux M, Joseph SA. Moxidectin for deworming: from trials to implementation. Lancet Infect Dis. 2018 Aug;18(8):817-819. doi: 10.1016/S1473-3099(18)30270-6. Epub 2018 May 29. PMID: 29858152.
19: Barda B, Ame SM, Ali SM, Albonico M, Puchkov M, Huwyler J, Hattendorf J, Keiser J. Efficacy and tolerability of moxidectin alone and in co-administration with albendazole and tribendimidine versus albendazole plus oxantel pamoate against Trichuris trichiura infections: a randomised, non-inferiority, single- blind trial. Lancet Infect Dis. 2018 Aug;18(8):864-873. doi: 10.1016/S1473-3099(18)30233-0. Epub 2018 May 29. PMID: 29858149.
20: Clarke NE, Doi SAR, Wangdi K, Chen Y, Clements ACA, Nery SV. Efficacy of Anthelminthic Drugs and Drug Combinations Against Soil-transmitted Helminths: A Systematic Review and Network Meta-analysis. Clin Infect Dis. 2019 Jan 1;68(1):96-105. doi: 10.1093/cid/ciy423. PMID: 29788074.
