WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H130601
CAS#: 183012-13-7
Description: YM116 is a C17-20 lyase inhibitor, decreasing adrenal androgen synthesis.
Hodoodo Cat#: H130601
Name: YM116
CAS#: 183012-13-7
Chemical Formula: C16H13N3
Exact Mass: 247.11
Molecular Weight: 247.300
Elemental Analysis: C, 77.71; H, 5.30; N, 16.99
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Synonym: YM 116, YM-116
IUPAC/Chemical Name: 2-(1H-Imidazol-5-ylmethyl)-9H-carbazole
InChi Key:
InChi Code:
SMILES Code:
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 247.30 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1. Akaza H, Tsukamoto S, Morita T, Yamauchi A, Onozawa M, Shimazui T, Ideyama Y, Shirai T. Promoting effects of antiandrogenic agents on rat ventral prostate carcinogenesis induced by 3,2'-dimethyl-4-aminobiphenyl (DMAB). Prostate Cancer Prostatic Dis. 2000 Aug;3(2):115-119. doi: 10.1038/sj.pcan.4500409. PMID: 12497109.
2. Ideyama Y, Kudoh M, Tanimoto K, Susaki Y, Nanya T, Nakahara T, Ishikawa H, Fujikura T, Akaza H, Shikama H. YM116, 2-(1H-imidazol-4-ylmethyl)-9H-carbazole, decreases adrenal androgen synthesis by inhibiting C17-20 lyase activity in NCI-H295 human adrenocortical carcinoma cells. Jpn J Pharmacol. 1999 Feb;79(2):213-20. doi: 10.1254/jjp.79.213. PMID: 10202857.
3. Ideyama Y, Kudoh M, Tanimoto K, Susaki Y, Nanya T, Nakahara T, Ishikawa H, Yoden T, Okada M, Fujikura T, Akaza H, Shikama H. Novel nonsteroidal inhibitor of cytochrome P450(17alpha) (17alpha-hydroxylase/C17-20 lyase), YM116, decreased prostatic weights by reducing serum concentrations of testosterone and adrenal androgens in rats. Prostate. 1998 Sep 15;37(1):10-8. doi: 10.1002/(sici)1097-0045(19980915)37:1<10::aid-pros3>3.0.co;2-c. PMID: 9721064.