CMLD-2
new
featured

    WARNING: This product is for research use only, not for human or veterinary use.

Hodoodo CAT#: H123922

CAS#: 958843-91-9

Description: CMLD-2 is an inhibitor of HuR-ARE interaction.

Chemical Structure

img
CMLD-2
CAS# 958843-91-9
Instruction

Theoretical Analysis

Hodoodo Cat#: H123922
Name: CMLD-2
CAS#: 958843-91-9
Chemical Formula: C31H31NO6
Exact Mass: 513.22
Molecular Weight: 513.590
Elemental Analysis: C, 72.50; H, 6.08; N, 2.73; O, 18.69

Price and Availability

Size Price Availability Quantity
50mg USD 750 2 Weeks
100mg USD 1250 2 Weeks
200mg USD 1950 2 Weeks
500mg USD 3450 2 Weeks
1g USD 4850 2 Weeks
2g USD 6850 2 Weeks
Bulk inquiry

Synonym: 958843-91-9; CMLD-2; MLS000879470; SMR000465530; CMLD2; CMLD 2

IUPAC/Chemical Name: 5,7-dimethoxy-8-(1-(4-methoxyphenyl)-3-oxo-3-(pyrrolidin-1-yl)propyl)-4-phenyl-2H-chromen-2-one

InChi Key: PROGRNRRJJYCNX-UHFFFAOYSA-N

InChi Code: InChI=1S/C31H31NO6/c1-35-22-13-11-21(12-14-22)23(17-27(33)32-15-7-8-16-32)29-25(36-2)19-26(37-3)30-24(18-28(34)38-31(29)30)20-9-5-4-6-10-20/h4-6,9-14,18-19,23H,7-8,15-17H2,1-3H3

SMILES Code: O=C1C=C(C2=CC=CC=C2)C3=C(OC)C=C(OC)C(C(C4=CC=C(OC)C=C4)CC(N5CCCC5)=O)=C3O1

Appearance: To be determined

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 513.59 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

1: Allegri L, Baldan F, Roy S, Aubé J, Russo D, Filetti S, Damante G. The HuR
CMLD-2 inhibitor exhibits antitumor effects via MAD2 downregulation in thyroid
cancer cells. Sci Rep. 2019 May 14;9(1):7374. doi: 10.1038/s41598-019-43894-0.
PMID: 31089242; PMCID: PMC6517587.

2: Muralidharan R, Mehta M, Ahmed R, Roy S, Xu L, Aubé J, Chen A, Zhao YD,
Herman T, Ramesh R, Munshi A. HuR-targeted small molecule inhibitor exhibits
cytotoxicity towards human lung cancer cells. Sci Rep. 2017 Aug 30;7(1):9694.
doi: 10.1038/s41598-017-07787-4. PMID: 28855578; PMCID: PMC5577245.

3: Kunder N, de la Peña JB, Lou TF, Chase R, Suresh P, Lawson J, Shukla T, Black
B, Campbell ZT. The RNA-Binding Protein HuR Is Integral to the Function of
Nociceptors in Mice and Humans. J Neurosci. 2022 Dec 7;42(49):9129-9141. doi:
10.1523/JNEUROSCI.1630-22.2022. Epub 2022 Oct 21. PMID: 36270801; PMCID:
PMC9761683.