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S1R agonist 2
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WARNING: This product is for research use only, not for human or veterinary use.

Hodoodo CAT#: H123934

CAS#: 150085-21-5

Description: S1R agonist 2 (Compound 8b) is a selective S1R agonist.

Chemical Structure

S1R agonist 2

CAS# 150085-21-5

Instruction

Theoretical Analysis

Hodoodo Cat#: H123934
Name: S1R agonist 2
CAS#: 150085-21-5
Chemical Formula: C21H27NO
Exact Mass: 309.21
Molecular Weight: 309.450
Elemental Analysis: C, 81.51; H, 8.79; N, 4.53; O, 5.17

Price and Availability

Size	Price	Availability
100mg	USD 750	2 Weeks
200mg	USD 1250	2 Weeks
500mg	USD 2850	2 Weeks
1g	USD 3450	2 Weeks
2g	USD 5650	2 Weeks
Bulk inquiry Welcome, Customer: Please do not inquire quote if your intended use is for a patient since our products are for research use and for chemical synthesis use, not for human use . For in-stock products, we listed price in the web page. You may inquire prices for which sizes were not listed. If no price is listed, this means the product is not in stock at the moment, which may be available via custom synthesis. For cost-effective reason, minimum order of 1g is requested (typically very expensive). The lead time is usually 2-4 months. Quote of less than 1g will not be provided. Hodoodo may not offer quote for below reasons: (1) current available synthetic method appears to be extremely expensive which is obviously not affordable to most customers; (2) Key raw material to make the product is temporally not available; (3) DEA controlled substances; (4) the product is under patent protection in customer’s country.

Synonym: 150085-21-5; S1R agonist; S1R agonist-2; S1R-agonist-2; Compound 8b

IUPAC/Chemical Name: 4-benzyl-1-(3-phenoxypropyl)piperidine

InChi Key: KOYQYIAABUPJFF-UHFFFAOYSA-N

InChi Code: InChI=1S/C21H27NO/c1-3-8-19(9-4-1)18-20-12-15-22(16-13-20)14-7-17-23-21-10-5-2-6-11-21/h1-6,8-11,20H,7,12-18H2

SMILES Code: C1(OCCCN2CCC(CC2)CC3=CC=CC=C3)=CC=CC=C1

Appearance: To be determined

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Instruction:

View handling instruction

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 309.45 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Váczi S, Barna L, Harazin A, Mészáros M, Porkoláb G, Zvara Á, Ónody R,
Földesi I, Veszelka S, Penke B, Fülöp L, Deli MA, Mezei Z. S1R agonist modulates
rat platelet eicosanoid synthesis and aggregation. Platelets. 2022 Jul
4;33(5):709-718. doi: 10.1080/09537104.2021.1981843. Epub 2021 Oct 26. PMID:
34697991.

2: Dalwadi DA, Kim S, Schetz J, Schreihofer DA, Kim S. Brain-derived
neurotrophic factor for high-throughput evaluation of selective Sigma-1 receptor
ligands. J Pharmacol Toxicol Methods. 2022 Jan-Feb;113:107129. doi:
10.1016/j.vascn.2021.107129. Epub 2021 Oct 20. PMID: 34678430; PMCID:
PMC9358981.

3: Mavlyutov TA, Baker EM, Losenegger TM, Kim JR, Torres B, Epstein ML, Ruoho
AE. The Sigma-1 Receptor-A Therapeutic Target for the Treatment of ALS? Adv Exp
Med Biol. 2017;964:255-265. doi: 10.1007/978-3-319-50174-1_17. PMID: 28315276.

4: Zhemkov V, Geva M, Hayden MR, Bezprozvanny I. Sigma-1 Receptor (S1R)
Interaction with Cholesterol: Mechanisms of S1R Activation and Its Role in
Neurodegenerative Diseases. Int J Mol Sci. 2021 Apr 15;22(8):4082. doi:
10.3390/ijms22084082. PMID: 33920913; PMCID: PMC8071319.

5: Dichiara M, Ambrosio FA, Barbaraci C, González-Cano R, Costa G, Parenti C,
Marrazzo A, Pasquinucci L, Cobos EJ, Alcaro S, Amata E. Synthesis, Computational
Insights, and Evaluation of Novel Sigma Receptors Ligands. ACS Chem Neurosci.
2023 May 17;14(10):1845-1858. doi: 10.1021/acschemneuro.3c00074. Epub 2023 May
8. PMID: 37155827; PMCID: PMC10197133.

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