WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H123953
CAS#: 1448706-15-7
Description: Amgen-23 (compound 23) is a potent sphingosine kinases (SPHK) inhibitor
Hodoodo Cat#: H123953
Name: Amgen-23
CAS#: 1448706-15-7
Chemical Formula: C23H25Cl2N3O2S
Exact Mass: 477.10
Molecular Weight: 478.430
Elemental Analysis: C, 57.74; H, 5.27; Cl, 14.82; N, 8.78; O, 6.69; S, 6.70
Synonym: Amgen-23; Compund 23; CHEMBL2409865; BDBM50438132; MS-28873
IUPAC/Chemical Name: (2R,4S)-1-[2-[4-[[4-(3,4-dichlorophenyl)-1,3-thiazol-2-yl]amino]phenyl]ethyl]-2-(hydroxymethyl)piperidin-4-ol
InChi Key: SQJKFWCRPARYPY-MOPGFXCFSA-N
InChi Code: InChI=1S/C23H25Cl2N3O2S/c24-20-6-3-16(11-21(20)25)22-14-31-23(27-22)26-17-4-1-15(2-5-17)7-9-28-10-8-19(30)12-18(28)13-29/h1-6,11,14,18-19,29-30H,7-10,12-13H2,(H,26,27)/t18-,19+/m1/s1
SMILES Code: O[C@@H]1C[C@H](CO)N(CCC2=CC=C(NC3=NC(C4=CC=C(Cl)C(Cl)=C4)=CS3)C=C2)CC1
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
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The following data is based on the product molecular weight 478.43 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |