KI-ARv-03

    WARNING: This product is for research use only, not for human or veterinary use.

Hodoodo CAT#: H123997

CAS#: N/A

Description: KI-ARv-03 is a potent, selective inhibitor of CDK9, an important cofactor for AR, MYC, and other oncogenic transcription factors.

Chemical Structure

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KI-ARv-03
CAS# N/A
Instruction

Theoretical Analysis

Hodoodo Cat#: H123997
Name: KI-ARv-03
CAS#: N/A
Chemical Formula: C14H21N5
Exact Mass: 259.18
Molecular Weight: 259.360
Elemental Analysis: C, 64.83; H, 8.16; N, 27.00

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @hodoodo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: KI-ARv-03; KI ARv-03; KI-ARv 03

IUPAC/Chemical Name: (1R,3R)-N1-(5-propylpyrazolo[1,5-a]pyrimidin-7-yl)cyclopentane-1,3-diamine

InChi Key: JTBZUSIDMCXPIU-ZYHUDNBSSA-N

InChi Code: InChI=1S/C14H21N5/c1-2-3-11-9-14(18-12-5-4-10(15)8-12)19-13(17-11)6-7-16-19/h6-7,9-10,12,18H,2-5,8,15H2,1H3/t10-,12-/m1/s1

SMILES Code: CCCC1=NC2=CC=NN2C(N[C@@H]3CC[C@@H](N)C3)=C1

Appearance: To be determined

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 259.36 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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Richters A, Doyle SK, Freeman DB, Lee C, Leifer BS, Jagannathan S, Kabinger F, Koren JV, Struntz NB, Urgiles J, Stagg RA, Curtin BH, Chatterjee D, Mathea S, Mikochik PJ, Hopkins TD, Gao H, Branch JR, Xin H, Westover L, Bignan GC, Rupnow BA, Karlin KL, Olson CM, Westbrook TF, Vacca J, Wilfong CM, Trotter BW, Saffran DC, Bischofberger N, Knapp S, Russo JW, Hickson I, Bischoff JR, Gottardis MM, Balk SP, Lin CY, Pop MS, Koehler AN. Modulating Androgen Receptor-Driven Transcription in Prostate Cancer with Selective CDK9 Inhibitors. Cell Chem Biol. 2021 Feb 18;28(2):134-147.e14. doi: 10.1016/j.chembiol.2020.10.001. Epub 2020 Oct 20. PMID: 33086052.