WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H124045
CAS#: N/A
Description: OP-1250 is a potent orally available complete antagonist of estrogen receptor-mediated signaling that shrinks wild type and mutant breast tumors. OP-1250 shows good oral bioavailability and favorable pharmacokinetics, a combination that may particularly benefit ER+ resistant tumors in which the receptor acquires activating mutations that confer estrogen-independent agonist activity.
Hodoodo Cat#: H124045
Name: OP-1250
CAS#: N/A
Chemical Formula: C28H34F3N3O
Exact Mass: 485.27
Molecular Weight: 485.600
Elemental Analysis: C, 69.26; H, 7.06; F, 11.74; N, 8.65; O, 3.29
This product is not in stock, which may be available by custom synthesis.
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Synonym: OP-1250; OP 1250; OP 1250
IUPAC/Chemical Name: (1R,3R)-1-(2,6-difluoro-4-((1-propylazetidin-3-yl)oxy)phenyl)-2-(2-fluoro-2-methylpropyl)-3-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole
InChi Key: VJYIQQTZNGFHGR-XGCWNURASA-N
InChi Code: InChI=1S/C28H34F3N3O/c1-5-10-33-14-19(15-33)35-18-12-22(29)25(23(30)13-18)27-26-21(20-8-6-7-9-24(20)32-26)11-17(2)34(27)16-28(3,4)31/h6-9,12-13,17,19,27,32H,5,10-11,14-16H2,1-4H3/t17-,27-/m1/s1
SMILES Code: C[C@@H](N(CC(C)(F)C)[C@@H]1C2=C(F)C=C(OC3CN(CCC)C3)C=C2F)CC4=C1NC5=C4C=CC=C5
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
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The following data is based on the product molecular weight 485.60 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |