WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H124044
CAS#: N/A
Description: ZY19489 is an antimalarial agent.
Hodoodo Cat#: H124044
Name: ZY19489
CAS#: N/A
Chemical Formula: C24H32FN9
Exact Mass: 465.28
Molecular Weight: 465.580
Elemental Analysis: C, 61.91; H, 6.93; F, 4.08; N, 27.08
This product is not in stock, which may be available by custom synthesis.
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Synonym: MMV253; ZY19489; MMV-253; VL8W9427Y4; ZY-19489
IUPAC/Chemical Name: 2-N-(4-cyclopropyl-5-fluoro-6-methylpyridin-2-yl)-5-[(3R)-3,4-dimethylpiperazin-1-yl]-4-N-(1,5-dimethylpyrazol-3-yl)pyrimidine-2,4-diamine
InChi Key: HKPQFVAUXAZCDY-OAHLLOKOSA-N
InChi Code: InChI=1S/C24H32FN9/c1-14-10-21(31-33(14)5)28-23-19(34-9-8-32(4)15(2)13-34)12-26-24(30-23)29-20-11-18(17-6-7-17)22(25)16(3)27-20/h10-12,15,17H,6-9,13H2,1-5H3,(H2,26,27,28,29,30,31)/t15-/m1/s1
SMILES Code: CC1=CC(NC2=NC(NC3=NC(C)=C(F)C(C4CC4)=C3)=NC=C2N5C[C@@H](C)N(C)CC5)=NN1C
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
| Biological target: | |
| In vitro activity: | |
| In vivo activity: |
The following data is based on the product molecular weight 465.58 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
1: Ghoghari AM, Patel HV, Nayak NN, Mansuri TH, Pillai SM, Jain MR, Patel HB,
Kansagra K, Resta ID, Möhrle J, Parmar DV. Simultaneous estimation of ZY-19489
and its active metabolite ZY-20486 in human plasma using LC-MS/MS, a novel
antimalarial compound. Bioanalysis. 2021 Dec;13(23):1761-1777. doi:
10.4155/bio-2021-0194. Epub 2021 Nov 15. PMID: 34779650.
2: Radohery GFR, Gower J, Barber BE, Kansagra K, Möhrle JJ, Davenport MP,
McCarthy JS, Khoury DS, Rebelo M. Effect of novel antimalarial ZY-19489 on
Plasmodium falciparum viability in a volunteer infection study. Lancet Infect
Dis. 2022 Jun;22(6):760-761. doi: 10.1016/S1473-3099(22)00294-8. PMID: 35643094.
3: Barber BE, Fernandez M, Patel HB, Barcelo C, Woolley SD, Patel H, Llewellyn
S, Abd-Rahman AN, Sharma S, Jain M, Ghoghari A, Di Resta I, Fuchs A, Deni I, Yeo
T, Mok S, Fidock DA, Chalon S, Möhrle JJ, Parmar D, McCarthy JS, Kansagra K.
Safety, pharmacokinetics, and antimalarial activity of the novel
triaminopyrimidine ZY-19489: a first-in-human, randomised, placebo-controlled,
double-blind, single ascending dose study, pilot food-effect study, and
volunteer infection study. Lancet Infect Dis. 2022 Jun;22(6):879-890. doi:
10.1016/S1473-3099(21)00679-4. Epub 2022 Mar 2. PMID: 35247321.
