WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H124068
CAS#: 2351225-46-0
Description: NSD1 inhibitor BT5 is a covalent, small molecule inhibitor of NSD1 histone methyltransferase.
Hodoodo Cat#: H124068
Name: NSD1 inhibitor BT5
CAS#: 2351225-46-0
Chemical Formula: C10H11N3OS
Exact Mass: 221.06
Molecular Weight: 221.280
Elemental Analysis: C, 54.28; H, 5.01; N, 18.99; O, 7.23; S, 14.49
Synonym: 2-Amino-6-(2-methylaziridin-1-yl)-1,3-benzothiazol-4-ol; 2351225-46-0; NSD1 inhibitor BT5; SCHEMBL21091275; EX-A6865
IUPAC/Chemical Name: 2-amino-6-(2-methylaziridin-1-yl)-1,3-benzothiazol-4-ol
InChi Key: PHBIAWCGMOCBGF-UHFFFAOYSA-N
InChi Code: InChI=1S/C10H11N3OS/c1-5-4-13(5)6-2-7(14)9-8(3-6)15-10(11)12-9/h2-3,5,14H,4H2,1H3,(H2,11,12)
SMILES Code: OC1=C2N=C(N)SC2=CC(N3C(C)C3)=C1
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
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The following data is based on the product molecular weight 221.28 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
Huang H, Howard CA, Zari S, Cho HJ, Shukla S, Li H, Ndoj J, González-Alonso P, Nikolaidis C, Abbott J, Rogawski DS, Potopnyk MA, Kempinska K, Miao H, Purohit T, Henderson A, Mapp A, Sulis ML, Ferrando A, Grembecka J, Cierpicki T. Covalent inhibition of NSD1 histone methyltransferase. Nat Chem Biol. 2020 Dec;16(12):1403-1410. doi: 10.1038/s41589-020-0626-6. Epub 2020 Aug 31. PMID: 32868895; PMCID: PMC7669657.