WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H124128
CAS#: 2566715-93-1
Description: KSK67 is a high-affinity dual sigma-2 and histamine H3 receptor antagonist.
Hodoodo Cat#: H124128
Name: KSK67
CAS#: 2566715-93-1
Chemical Formula: C22H27N3O2
Exact Mass: 365.21
Molecular Weight: 365.480
Elemental Analysis: C, 72.30; H, 7.45; N, 11.50; O, 8.76
Synonym: KSK67; KSK-67; KSK 67
IUPAC/Chemical Name: cyclopropyl(4-(3-(4-(pyridin-4-yl)piperazin-1-yl)propoxy)phenyl)methanone
InChi Key: MHFUOIGTIQCKRH-UHFFFAOYSA-N
InChi Code: InChI=1S/C22H27N3O2/c26-22(18-2-3-18)19-4-6-21(7-5-19)27-17-1-12-24-13-15-25(16-14-24)20-8-10-23-11-9-20/h4-11,18H,1-3,12-17H2
SMILES Code: O=C(C1CC1)C2=CC=C(C=C2)OCCCN(CC3)CCN3C4=CC=NC=C4
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
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The following data is based on the product molecular weight 365.48 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
Szczepańska K, Karcz T, Dichiara M, Mogilski S, Kalinowska-Tłuścik J, Pilarski B, Leniak A, Pietruś W, Podlewska S, Popiołek-Barczyk K, Humphrys LJ, Ruiz-Cantero MC, Reiner-Link D, Leitzbach L, Łażewska D, Pockes S, Górka M, Zmysłowski A, Calmels T, Cobos EJ, Marrazzo A, Stark H, Bojarski AJ, Amata E, Kieć-Kononowicz K. Dual Piperidine-Based Histamine H3 and Sigma-1 Receptor Ligands in the Treatment of Nociceptive and Neuropathic Pain. J Med Chem. 2023 Jul 7. doi: 10.1021/acs.jmedchem.3c00430. Epub ahead of print. PMID: 37418295.