WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H124134
CAS#: N/A
Description: NS-062 is an EGFR inhibitor.
Hodoodo Cat#: H124134
Name: NS-062
CAS#: N/A
Chemical Formula: C28H30Cl2F2N6O4
Exact Mass: 622.17
Molecular Weight: 623.480
Elemental Analysis: C, 53.94; H, 4.85; Cl, 11.37; F, 6.09; N, 13.48; O, 10.26
This product is not in stock, which may be available by custom synthesis.
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Synonym: NS-062; NS062; NS 062
IUPAC/Chemical Name: (2R)-1-(2-chloro-2-fluoroacetyl)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-(3-morpholinopropoxy)quinazolin-6-yl)pyrrolidine-2-carboxamide
InChi Key: CNRKPZFTXUAKCP-XQZUBTRRSA-N
InChi Code: InChI=1S/C28H30Cl2F2N6O4/c29-19-13-17(4-5-20(19)31)35-26-18-14-22(36-27(39)23-3-1-7-38(23)28(40)25(30)32)24(15-21(18)33-16-34-26)42-10-2-6-37-8-11-41-12-9-37/h4-5,13-16,23,25H,1-3,6-12H2,(H,36,39)(H,33,34,35)/t23-,25?/m1/s1
SMILES Code: FC1=CC=C(NC2=NC=NC3=C2C=C(NC([C@H]4CCCN4C(C(Cl)F)=O)=O)C(OCCCN5CCOCC5)=C3)C=C1Cl
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 623.48 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
Shindo N, Fuchida H, Sato M, Watari K, Shibata T, Kuwata K, Miura C, Okamoto K, Hatsuyama Y, Tokunaga K, Sakamoto S, Morimoto S, Abe Y, Shiroishi M, Caaveiro JMM, Ueda T, Tamura T, Matsunaga N, Nakao T, Koyanagi S, Ohdo S, Yamaguchi Y, Hamachi I, Ono M, Ojida A. Selective and reversible modification of kinase cysteines with chlorofluoroacetamides. Nat Chem Biol. 2019 Mar;15(3):250-258. doi: 10.1038/s41589-018-0204-3. Epub 2019 Jan 14. PMID: 30643284.