WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H124132
CAS#: N/A
Description: S07-1066 is an Aldo-Keto Reductase 1C3 (AKR1C3) Inhibitor for Reversing AKR1C3-Mediated Drug Resistance in Cancer Treatment. S07-1066 selectively blocked AKR1C3-mediated reduction of doxorubicin (DOX) in MCF-7 transfected cell models. Furthermore, co-treatment of S07-1066 significantly synergized DOX cytotoxicity and reversed the DOX resistance in MCF-7 cells overexpressing AKR1C3. The potential synergism of S07-1066 over DOX cytotoxicity was demonstrated in vitro and in vivo.
Hodoodo Cat#: H124132
Name: S07-1066
CAS#: N/A
Chemical Formula: C16H11Cl2FO2
Exact Mass: 324.01
Molecular Weight: 325.160
Elemental Analysis: C, 59.10; H, 3.41; Cl, 21.80; F, 5.84; O, 9.84
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Synonym: S07-1066; S071066; S07 1066
IUPAC/Chemical Name: 1-(3',5'-dichloro-2-fluoro-[1,1'-biphenyl]-4-yl)cyclopropane-1-carboxylic acid
InChi Key: DFJGLZRYGZSQOR-UHFFFAOYSA-N
InChi Code: InChI=1S/C16H11Cl2FO2/c17-11-5-9(6-12(18)8-11)13-2-1-10(7-14(13)19)16(3-4-16)15(20)21/h1-2,5-8H,3-4H2,(H,20,21)
SMILES Code: ClC1=CC(C2=CC=C(C3(C(O)=O)CC3)C=C2F)=CC(Cl)=C1
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 325.16 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
He S, Chu X, Wu Y, Jiang J, Fang P, Chen Y, Liu Y, Qiu Z, Xiao Y, Li Z, Pan D, Zhang Q, Xie H, Xing S, Feng F, Liu W, Guo Q, Zhao L, Yang P, Sun H. Development of Biaryl-Containing Aldo-Keto Reductase 1C3 (AKR1C3) Inhibitors for Reversing AKR1C3-Mediated Drug Resistance in Cancer Treatment. J Med Chem. 2023 Jul 6. doi: 10.1021/acs.jmedchem.3c00213. Epub ahead of print. PMID: 37409679.