WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H124227
CAS#: 936616-33-0
Description: XEP-018, also known as μ-Conotoxin Cn IIIC, is a biomimetic of a natural conopeptide from venomous marine cone snail (Conus consors). Biologically, it acts as a modulator of the neuromuscular transmission, as well as a potent and selective blocker of the voltage-gated sodium channel Nav 1.4. Cosmetically, it acts as an instant line relaxer giving a smooth skin appearance.
Hodoodo Cat#: H124227
Name: XEP-018
CAS#: 936616-33-0
Chemical Formula: C92H139N35O28S6
Exact Mass: 2,373.89
Molecular Weight: 2,375.700
Elemental Analysis: C, 46.51; H, 5.90; N, 20.64; O, 18.86; S, 8.10
Synonym: Mu-Conotoxin; XEP-018; CONOTOXIN; ACETY TETRAPEPTIDE-9; Cono Antiwrinkle; 936616-33-0; μ-Conotoxin Cn IIIC
IUPAC/Chemical Name: 2-((3S,9R,12S,15S,18S,21S,24R,27S,30S,33S,36S,39S,42R,47R,50S,58aS,61R,68R)-33-((1H-imidazol-5-yl)methyl)-21-((1H-indol-3-yl)methyl)-50-(2-amino-2-oxoethyl)-3,18-bis(4-aminobutyl)-68-carbamoyl-27,39-bis(3-guanidinopropyl)-12,15-bis(hydroxymethyl)-36-methyl-1,4,7,10,13,16,19,22,25,28,31,34,37,40,48,51,54,60,66-nonadecaoxo-61-(2-((S)-5-oxopyrrolidine-2-carboxamido)acetamido)tetrapentacontahydro-1H,46H-47,24-(epiminopropanodithiomethano)-9,42-(methanodithioethanoiminomethano)pyrrolo[2,1-t1][1,2]dithia[5,8,11,14,17,20,23,26,29,32,35,38,41,44,47,50,53]heptadecaazacyclohexapentacontin-30-yl)acetic acid
InChi Key: PQKXBHZHSUVYIL-XAASTXGFSA-N
InChi Code: InChI=1S/C92H139N35O28S6/c1-43-73(138)113-50(15-8-22-102-91(97)98)79(144)124-64-41-161-160-40-63-88(153)119-55(27-66(95)130)76(141)107-33-70(134)127-24-10-17-65(127)90(155)116-48(13-4-6-20-93)74(139)105-31-68(132)111-60(37-157-156-36-59(72(96)137)123-89(64)154)85(150)122-58(35-129)84(149)121-57(34-128)83(148)114-49(14-5-7-21-94)77(142)117-53(25-44-29-104-47-12-3-2-11-46(44)47)81(146)125-62(39-159-158-38-61(86(151)126-63)112-69(133)32-106-75(140)52-18-19-67(131)110-52)87(152)115-51(16-9-23-103-92(99)100)78(143)120-56(28-71(135)136)82(147)118-54(80(145)109-43)26-45-30-101-42-108-45/h2-3,11-12,29-30,42-43,48-65,104,128-129H,4-10,13-28,31-41,93-94H2,1H3,(H2,95,130)(H2,96,137)(H,101,108)(H,105,139)(H,106,140)(H,107,141)(H,109,145)(H,110,131)(H,111,132)(H,112,133)(H,113,138)(H,114,148)(H,115,152)(H,116,155)(H,117,142)(H,118,147)(H,119,153)(H,120,143)(H,121,149)(H,122,150)(H,123,154)(H,124,144)(H,125,146)(H,126,151)(H,135,136)(H4,97,98,102)(H4,99,100,103)/t43-,48-,49-,50-,51-,52-,53-,54-,55-,56-,57-,58-,59-,60-,61-,62-,63-,64-,65-/m0/s1
SMILES Code: O=C(N[C@]1([H])C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@]2([H])CSSC[C@](C(N[C@H](C(NCC(N3[C@](CCC3)([H])C(N[C@H](C(NCC(N[C@](CSSC[C@H](NC2=O)C(N)=O)([H])C(N[C@H](C(N[C@H](C(N[C@H](C(N4)=O)CCCCN)=O)CO)=O)CO)=O)=O)=O)CCCCN)=O)=O)=O)CC(N)=O)=O)([H])NC([C@H](CSSC1)NC(CNC([C@@H]5CCC(N5)=O)=O)=O)=O)=O)CCCNC(N)=N)=O)C)=O)CC6=CN=CN6)=O)CC(O)=O)=O)CCCNC(N)=N)=O)[C@@H]4CC7=CNC8=CC=CC=C78
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
| Biological target: | |
| In vitro activity: | |
| In vivo activity: |
The following data is based on the product molecular weight 2,375.70 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
1: Leone-Bay A. Natural peptides to drugs - fourth international congress.
IDrugs. 2010 Jun;13(6):369-71. PMID: 20506056.
