WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H124259
CAS#: 374856-75-2
Description: Evixapodlin, also known as GS-4224, is a PD-L1 inhibitor with an IC50 of 0.213 nM. GS-4224 specifically targets PD-L1 expressed on tumor cells preventing the binding and subsequent activation of its receptor, programmed cell death 1 (PD-1; PDCD1; CD279; programmed death-1). This reverses T-cell inactivation caused by PD-L1/PD-1 signaling, increases T-cell expansion and enhances the cytotoxic T-lymphocyte (CTL)-mediated anti-tumor immune response against PD-L1-expressing tumor cells. It may also enhance hepatitis B virus (HBV)-specific CD8+ T-cell function, thereby killing HBV-infected cells. PD-L1, a transmembrane protein expressed on activated T-cells, is overexpressed in some cancer types and plays a significant role in immune evasion by tumor cells. It is also upregulated in HBV-positive patients and contributes to immune dysfunction against HBV infection.
Hodoodo Cat#: H124259
Name: Evixapodlin
CAS#: 374856-75-2
Chemical Formula: C40H36BrCl2N3O8S
Exact Mass: 867.08
Molecular Weight: 869.610
Elemental Analysis: C, 55.25; H, 4.17; Br, 9.19; Cl, 8.15; N, 4.83; O, 14.72; S, 3.69
Synonym: GS-4224; GS4224; GS 4224; Evixapodlin;
IUPAC/Chemical Name: (R)-1-((5-bromo-6-((2,2'-dichloro-3'-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-[1,1'-biphenyl]-3-yl)methoxy)-2-((5-(methylsulfonyl)pyridin-3-yl)methoxy)pyridin-3-yl)methyl)piperidine-2-carboxylic acid
InChi Key: CSCGFASBLZSOLA-MGBGTMOVSA-N
InChi Code: InChI=1S/C40H36BrCl2N3O8S/c1-55(49,50)28-16-24(19-44-20-28)22-53-38-27(21-46-13-3-2-10-33(46)40(47)48)17-32(41)39(45-38)54-23-26-6-4-8-30(36(26)42)31-9-5-7-29(37(31)43)25-11-12-34-35(18-25)52-15-14-51-34/h4-9,11-12,16-20,33H,2-3,10,13-15,21-23H2,1H3,(H,47,48)/t33-/m1/s1
SMILES Code: ClC1=C(C2=C(Cl)C(COC3=NC(OCC4=CC(S(C)(=O)=O)=CN=C4)=C(CN5[C@@H](C(O)=O)CCCC5)C=C3Br)=CC=C2)C=CC=C1C(C=C6)=CC7=C6OCCO7
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
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The following data is based on the product molecular weight 869.61 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
