WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H124271
CAS#: N/A
Description: HPG1860 is a potent full FXR agonist. HPG1860 shows high selectivity, favorable ADME and pharmacokinetics profile, along with favorable in vivo activities demonstrated in both rodent PD model and HFD-CCl4 model
Hodoodo Cat#: H124271
Name: HPG1860
CAS#: N/A
Chemical Formula: C27H26Cl2N4O4S
Exact Mass: 572.11
Molecular Weight: 573.490
Elemental Analysis: C, 56.55; H, 4.57; Cl, 12.36; N, 9.77; O, 11.16; S, 5.59
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Synonym: HPG1860; HPG-1860; HPG 1860
IUPAC/Chemical Name: (R)-2-(4-((5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)methyl)-2-methylpiperazin-1-yl)-4-methoxybenzo[d]thiazole-6-carboxylic acid
InChi Key: JPEHHEUXHNQIIX-CQSZACIVSA-N
InChi Code: InChI=1S/C27H26Cl2N4O4S/c1-14-12-32(8-9-33(14)27-30-24-20(36-2)10-16(26(34)35)11-21(24)38-27)13-17-23(31-37-25(17)15-6-7-15)22-18(28)4-3-5-19(22)29/h3-5,10-11,14-15H,6-9,12-13H2,1-2H3,(H,34,35)/t14-/m1/s1
SMILES Code: ClC1=CC=CC(Cl)=C1C2=NOC(C3CC3)=C2CN4CCN(C5=NC6=C(C=C(C(O)=O)C=C6OC)S5)[C@H](C)C4
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 573.49 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
Mo C, Xu X, Zhang P, Peng Y, Zhao X, Chen S, Guo F, Xiong Y, Chu XJ, Xu X. Discovery of HPG1860, a Structurally Novel Nonbile Acid FXR Agonist Currently in Clinical Development for the Treatment of Nonalcoholic Steatohepatitis. J Med Chem. 2023 Jul 9. doi: 10.1021/acs.jmedchem.3c00456. Epub ahead of print. PMID: 37424079.