JPC0323

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Hodoodo CAT#: H124272

CAS#: N/A

Description: JPC0323 is a selective 5-HT2CR or dual 5-HT2CR/5-HT2AR positive allosteric modulator (PAM). JPC0323 exhibited on-target properties, acceptable plasma exposure and brain penetration, as well as negligible displacement to orth osteric sites of ∼50 GPCRs and transporters. Furthermore, JPC0323 suppressed novelty-induced locomotor activity in a 5-HT2CRdependent manner, suggesting 5-HT2CR PAM, but not 5-HT2AR, activity at the level of the whole organism at the employed doses of JPC0323.

Chemical Structure

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JPC0323
CAS# N/A
Instruction

Theoretical Analysis

Hodoodo Cat#: H124272
Name: JPC0323
CAS#: N/A
Chemical Formula: C22H43NO4
Exact Mass: 385.32
Molecular Weight: 385.590
Elemental Analysis: C, 68.53; H, 11.24; N, 3.63; O, 16.60

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @hodoodo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: JPC0323; JPC-0323; JPC 0323

IUPAC/Chemical Name: N-(1,3-dihydroxy-2-(hydroxymethyl)propan-2-yl)oleamide

InChi Key: JLFKELVBPUSMGW-KTKRTIGZSA-N

InChi Code: InChI=1S/C22H43NO4/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-21(27)23-22(18-24,19-25)20-26/h9-10,24-26H,2-8,11-20H2,1H3,(H,23,27)/b10-9-

SMILES Code: CCCCCCCC/C=C\CCCCCCCC(NC(CO)(CO)CO)=O

Appearance: To be determined

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 385.59 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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Chen J, Garcia EJ, Merritt CR, Zamora JC, Bolinger AA, Pazdrak K, Stafford SJ, Mifflin RC, Wold EA, Wild CT, Chen H, Anastasio NC, Cunningham KA, Zhou J. Discovery of Novel Oleamide Analogues as Brain-Penetrant Positive Allosteric Serotonin 5-HT2C Receptor and Dual 5-HT2C/5-HT2A Receptor Modulators. J Med Chem. 2023 Jul 18. doi: 10.1021/acs.jmedchem.3c00908. Epub ahead of print. PMID: 37462530.