WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H124276
CAS#: N/A
Description: LNP1892 is a precision calcimimetic for the treatment of secondary hyperparathyroidism. LNP1892 showed excellent potency and a favorable pharmacokinetics profile, and lacked the liabilities of cinacalcet, making it a highly differentiated precision calcimimetic. In adenine-diet-induced chronic kidney disease (CKD) models, LNP1892 demonstrated robust and dose-dependent efficacy, as measured by plasma parathyroid hormone (PTH) levels. It also showed an excellent safety profile in animal studies. Phase 1 clinical trials with 23a in healthy volunteers confirmed its excellent safety, tolerability, and effectiveness in lowering PTH levels in a dose-dependent manner, without causing symptomatic hypocalcaemia. Encouraged by these promising results, LNP1892 was taken to a Phase 2 study in CKD patients.
Hodoodo Cat#: H124276
Name: LNP1892
CAS#: N/A
Chemical Formula: C30H29NO3
Exact Mass: 451.21
Molecular Weight: 451.570
Elemental Analysis: C, 79.80; H, 6.47; N, 3.10; O, 10.63
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Synonym: LNP1892; LNP 1892; LNP-1892
IUPAC/Chemical Name: 2-methyl-5-((2R,4S)-2-((((R)-1-(naphthalen-1-yl)ethyl)amino)methyl)chroman-4-yl)benzoic acid
InChi Key: KEZDVJDKMYHVIV-XCIGCYOISA-N
InChi Code: InChI=1S/C30H29NO3/c1-19-14-15-22(16-27(19)30(32)33)28-17-23(34-29-13-6-5-11-26(28)29)18-31-20(2)24-12-7-9-21-8-3-4-10-25(21)24/h3-16,20,23,28,31H,17-18H2,1-2H3,(H,32,33)/t20-,23-,28+/m1/s1
SMILES Code: OC(C1=CC([C@H]2C(C=CC=C3)=C3O[C@@H](CN[C@H](C)C4=C(C=CC=C5)C5=CC=C4)C2)=CC=C1C)=O
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
| Biological target: | |
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The following data is based on the product molecular weight 451.57 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
Shukla MR, Sadasivam G, Sarde A, Sayyed M, Pachpute V, Phadtare R, Walke N, Chaudhari VD, Loriya R, Khan T, Gote G, Pawar C, Tryambake M, Mahajan N, Gandhe A, Sabde S, Pawar S, Patil V, Modi D, Mehta M, Nigade P, Modak V, Ghodke R, Narasimham L, Bhonde M, Gundu J, Goel R, Shah C, Kulkarni S, Sharma S, Bakhle D, Kamboj RK, Palle VP. Discovery of LNP1892: A Precision Calcimimetic for the Treatment of Secondary Hyperparathyroidism. J Med Chem. 2023 Jul 13. doi: 10.1021/acs.jmedchem.3c00698. Epub ahead of print. PMID: 37442941.
