WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H124278
CAS#: N/A
Description: PRL-295 is a Keap1−Nrf2 inhibitor with IC50 = 73 nM.
Hodoodo Cat#: H124278
Name: PRL-295
CAS#: N/A
Chemical Formula: C27H24F3N3O8S2
Exact Mass: 639.10
Molecular Weight: 639.620
Elemental Analysis: C, 50.70; H, 3.78; F, 8.91; N, 6.57; O, 20.01; S, 10.02
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Synonym: PRL-295; PRL295; PRL 295
IUPAC/Chemical Name: N-(4-((4-methoxy-N-(2,2,2-trifluoroethyl)phenyl)sulfonamido)isoquinolin-1-yl)-N-((4-methoxyphenyl)sulfonyl)glycine
InChi Key: UVJKKKIWFDQRIO-UHFFFAOYSA-N
InChi Code: InChI=1S/C27H24F3N3O8S2/c1-40-18-7-11-20(12-8-18)42(36,37)32(16-25(34)35)26-23-6-4-3-5-22(23)24(15-31-26)33(17-27(28,29)30)43(38,39)21-13-9-19(41-2)10-14-21/h3-15H,16-17H2,1-2H3,(H,34,35)
SMILES Code: COC1=CC=C(S(=O)(N(CC(F)(F)F)C2=CN=C(N(S(=O)(C3=CC=C(OC)C=C3)=O)CC(O)=O)C4=C2C=CC=C4)=O)C=C1
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 639.62 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
Dayalan Naidu S, Suzuki T, Dikovskaya D, Knatko EV, Higgins M, Sato M, Novak M, Villegas JA, Moore TW, Yamamoto M, Dinkova-Kostova AT. The isoquinoline PRL-295 increases the thermostability of Keap1 and disrupts its interaction with Nrf2. iScience. 2021 Dec 27;25(1):103703. doi: 10.1016/j.isci.2021.103703. PMID: 35036882; PMCID: PMC8749459.