WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H124314
CAS#: 521297-42-7
Description: NPD-2975 is a potent Aantitrypanosomal agent with in vivo efficacy. NPD-2975 has an in vitro IC50 of 70 nM against T. b. brucei with no apparent toxicity against human MRC-5 lung fibroblasts.
Hodoodo Cat#: H124314
Name: NPD-2975
CAS#: 521297-42-7
Chemical Formula: C14H13FN4O
Exact Mass: 272.11
Molecular Weight: 272.280
Elemental Analysis: C, 61.76; H, 4.81; F, 6.98; N, 20.58; O, 5.88
Synonym: NPD-2975; NPD 2975; NPD2975
IUPAC/Chemical Name: 5-(4-fluorophenyl)-3-isopropyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one
InChi Key: OJEVXJSJYBCDSR-UHFFFAOYSA-N
InChi Code: InChI=1S/C14H13FN4O/c1-7(2)10-11-12(19-18-10)14(20)17-13(16-11)8-3-5-9(15)6-4-8/h3-7H,1-2H3,(H,18,19)(H,16,17,20)
SMILES Code: FC1=CC=C(C2=NC(C(C(C)C)=NN3)=C3C(N2)=O)C=C1
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
| Biological target: | |
| In vitro activity: | |
| In vivo activity: |
The following data is based on the product molecular weight 272.28 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
Zheng Y, van den Kerkhof M, van der Meer T, Gul S, Kuzikov M, Ellinger B, de Esch IJP, Siderius M, Matheeussen A, Maes L, Sterk GJ, Caljon G, Leurs R. Discovery of 5-Phenylpyrazolopyrimidinone Analogs as Potent Antitrypanosomal Agents with In Vivo Efficacy. J Med Chem. 2023 Jul 20. doi: 10.1021/acs.jmedchem.3c00161. Epub ahead of print. PMID: 37471520.
