WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H124467
CAS#: N/A
Description: CL-197 is a potent anti-HIV agent low cytotoxicity (EC50 = 0.9 nM, CC50 > 100 μM). It also shows potent inhibitory activities on drug resistant and clinical HIV-1 strains. Oral administration of CL-197 to Beagle dogs resulted in high levels of its bioactive form CL-197-TP in peripheral blood mononuclear cells, the HIV-1 target cells, where the resulting triphosphate exhibited a long-term intracellular retention and could prevent HIV-1 infection for an extended time. CL-197 displayed low in vivo toxicity and favorable pharmacokinetics profiles in Sprague-Dawley rats.
Hodoodo Cat#: H124467
Name: CL-197
CAS#: N/A
Chemical Formula: C12H11F2N5O3
Exact Mass: 311.08
Molecular Weight: 311.250
Elemental Analysis: C, 46.31; H, 3.56; F, 12.21; N, 22.50; O, 15.42
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Synonym: CL-197; HY-148191; CS-0615395; CL197; CL 197
IUPAC/Chemical Name: 5-(6-amino-2-fluoro-9H-purin-9-yl)-2-ethynyl-4-fluoro-2-(hydroxymethyl)tetrahydrofuran-3-ol
InChi Key: CKOSILJGTGQALV-UHFFFAOYSA-N
InChi Code: InChI=1S/C12H11F2N5O3/c1-2-12(3-20)7(21)5(13)10(22-12)19-4-16-6-8(15)17-11(14)18-9(6)19/h1,4-5,7,10,20-21H,3H2,(H2,15,17,18)
SMILES Code: C#CC1(C(C(C(O1)N2C=NC3=C(N=C(N=C32)F)N)F)O)CO
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
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The following data is based on the product molecular weight 311.25 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
