WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H124501
CAS#: 109683-61-6
Description: Utibapril (FPL 63547) is an ester prodrug of a novel thiadiazoline ACE inhibitor.
Hodoodo Cat#: H124501
Name: Utibapril
CAS#: 109683-61-6
Chemical Formula: C22H31N3O5S
Exact Mass: 449.20
Molecular Weight: 449.570
Elemental Analysis: C, 58.78; H, 6.95; N, 9.35; O, 17.79; S, 7.13
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Synonym: FPL 63547; Utibapril; 109683-61-6; Utibaprilo; Utibaprilum; Utibapril [INN:BAN]
IUPAC/Chemical Name: 5-(tert-butyl)-3-((1-ethoxy-1-oxo-4-phenylbutan-2-yl)alanyl)-2,3-dihydro-1,3,4-thiadiazole-2-carboxylic acid
InChi Key: FTYVYAGWBXTWTN-UHFFFAOYSA-N
InChi Code: InChI=1S/C22H31N3O5S/c1-6-30-20(29)16(13-12-15-10-8-7-9-11-15)23-14(2)17(26)25-18(19(27)28)31-21(24-25)22(3,4)5/h7-11,14,16,18,23H,6,12-13H2,1-5H3,(H,27,28)
SMILES Code: CCOC(=O)C(CCC1=CC=CC=C1)NC(C)C(=O)N2C(SC(=N2)C(C)(C)C)C(=O)O
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 449.57 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Buikema H, Pinto YM, van Geel PP, Rooks G, de Langen CD, de Graeff PA, van
Gilst WH. Differential inhibition of plasma versus tissue ACE by utibapril:
biochemical and functional evidence for inhibition of vascular ACE activity. J
Cardiovasc Pharmacol. 1997 May;29(5):684-91. doi:
10.1097/00005344-199705000-00018. PMID: 9213213.
2: Carr RD, Higgs L, Killingback PG, Nicol AK, O'Connor SE, Robson A, Wells E,
Simpson WT. Pharmacological properties of FPL 63547, a novel inhibitor of
angiotensin-converting enzyme. Br J Pharmacol. 1990 May;100(1):83-9. doi:
10.1111/j.1476-5381.1990.tb12056.x. PMID: 2164863; PMCID: PMC1917465.
3: Carr RD, Cooper AE, Hutchinson R, Mann J, O'Connor SE, Robinson DH, Wells E.
Preferential biliary elimination of FPL 63547, a novel inhibitor of angiotensin-
converting enzyme, in the rat. Br J Pharmacol. 1990 May;100(1):90-4. doi:
10.1111/j.1476-5381.1990.tb12057.x. PMID: 2164864; PMCID: PMC1917479.