WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H140234
CAS#: 2241039-81-4
Description: Londamocitinib, also known as AZD4604, is a highly potent and selective JAK1 inhibitor (IC50 = 0.54 nM). AZD4604 possesses sub-nanomolar potency for JAK1 and is >1000-fold selective over JAK2, JAK3, and TYK2 as determined by the ratio of JAK2, JAK3, and TYK2 IC50s, respectively, over JAK1 IC50.
Hodoodo Cat#: H140234
Name: Londamocitinib
CAS#: 2241039-81-4
Chemical Formula: C28H31F2N7O4S
Exact Mass: 599.21
Molecular Weight: 599.658
Elemental Analysis: C, 56.08; H, 5.21; F, 6.34; N, 16.35; O, 10.67; S, 5.35
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Synonym: Londamocitinib; JAK1-IN-7; AZD4604; 2241039-81-4; AZD-4604; JAC34RRR7S
IUPAC/Chemical Name: (2R)-N-(3-{5-fluoro-2-[2-fluoro-3-(methanesulfonyl)anilino]pyrimidin-4-yl}-1H-indol-7-yl)-3-methoxy-2-(4-methylpiperazin-1-yl)propanamide
InChi Key: JNUZADQZHYFJGW-JOCHJYFZSA-N
InChi Code: InChI=1S/C28H31F2N7O4S/c1-36-10-12-37(13-11-36)22(16-41-2)27(38)33-21-8-4-6-17-18(14-31-26(17)21)25-19(29)15-32-28(35-25)34-20-7-5-9-23(24(20)30)42(3,39)40/h4-9,14-15,22,31H,10-13,16H2,1-3H3,(H,33,38)(H,32,34,35)/t22-/m1/s1
SMILES Code: O=C(NC1=CC=CC2=C1NC=C2C3=NC(NC4=CC=CC(S(=O)(C)=O)=C4F)=NC=C3F)[C@H](N5CCN(C)CC5)COC
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
| Biological target: | |
| In vitro activity: | |
| In vivo activity: |
The following data is based on the product molecular weight 599.66 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
1: Nilsson M, Rhedin M, Hendrickx R, Berglund S, Piras A, Blomgran P, Cavallin
A, Collins M, Dahl G, Dekkak B, Ericsson T, Hagberg N, Holmberg AA, Leffler A,
Lundqvist AJ, Markou T, Pinkerton J, Rönnblom L, Siu S, Taylor V, Wennberg T,
Zervas D, Laurence ADJ, Mitra S, Belvisi MG, Birrell M, Borde A.
Characterization of Selective and Potent JAK1 Inhibitors Intended for the
Inhaled Treatment of Asthma. Drug Des Devel Ther. 2022 Aug 31;16:2901-2917. doi:
10.2147/DDDT.S354291. PMID: 36068788; PMCID: PMC9441147.
2: Nilsson M, Berggren K, Berglund S, Cerboni S, Collins M, Dahl G, Elmqvist D,
Grimster NP, Hendrickx R, Johansson JR, Kettle JG, Lepistö M, Rhedin M,
Smailagic A, Su Q, Wennberg T, Wu A, Österlund T, Naessens T, Mitra S. Discovery
of the Potent and Selective Inhaled Janus Kinase 1 Inhibitor AZD4604 and Its
Preclinical Characterization. J Med Chem. 2023 Sep 22. doi:
10.1021/acs.jmedchem.3c00554. Epub ahead of print. PMID: 37738648.
