Acevaltrate

    WARNING: This product is for research use only, not for human or veterinary use.

Hodoodo CAT#: H124696

CAS#: 25161-41-5

Description: Acevaltrate is an iridoid found in variable amounts in Valerianaceae and might be among the bioactive compounds which confer anxiolytic properties to the Valeriana species.

Chemical Structure

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Acevaltrate
CAS# 25161-41-5
Instruction

Theoretical Analysis

Hodoodo Cat#: H124696
Name: Acevaltrate
CAS#: 25161-41-5
Chemical Formula: C24H32O10
Exact Mass: 480.20
Molecular Weight: 480.510
Elemental Analysis: C, 59.99; H, 6.71; O, 33.30

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @hodoodo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: Acevaltrate; 25161-41-5; Acevaltratum; Acetoxyvaltrate;

IUPAC/Chemical Name: [(1S,6S,7R,7aS)-4-(acetyloxymethyl)-1-(3-methylbutanoyloxy)spiro[6,7a-dihydro-1H-cyclopenta[c]pyran-7,2'-oxirane]-6-yl] 3-acetyloxy-3-methylbutanoate

InChi Key: FWKBQAVMKVZEOT-STCFVSJZSA-N

InChi Code: InChI=1S/C24H32O10/c1-13(2)7-19(27)33-22-21-17(16(11-30-22)10-29-14(3)25)8-18(24(21)12-31-24)32-20(28)9-23(5,6)34-15(4)26/h8,11,13,18,21-22H,7,9-10,12H2,1-6H3/t18-,21+,22-,24+/m0/s1

SMILES Code: CC(C)(OC(C)=O)CC(O[C@H]([C@@]12OC2)C=C3[C@]1([H])[C@H](OC(CC(C)C)=O)OC=C3COC(C)=O)=O

Appearance: To be determined

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 480.51 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Sun T, Xu YJ, Jiang SY, Xu Z, Cao BY, Sethi G, Zeng YY, Kong Y, Mao XL.
Suppression of the USP10/CCND1 axis induces glioblastoma cell apoptosis. Acta
Pharmacol Sin. 2021 Aug;42(8):1338-1346. doi: 10.1038/s41401-020-00551-x. Epub
2020 Nov 12. PMID: 33184448; PMCID: PMC8285505.

2: Sun T, Xu Y, Xu Z, Cao B, Zhang Z, Wang Q, Kong Y, Mao X. Inhibition of the
Otub1/c-Maf axis by the herbal acevaltrate induces myeloma cell apoptosis. Cell
Commun Signal. 2021 Feb 24;19(1):24. doi: 10.1186/s12964-020-00676-w. PMID:
33627137; PMCID: PMC7905600.

3: Bettero GM, Salles L, Rosário Figueira RM, Poser Gv, Rates SM, Noël F,
Quintas LE. In vitro effect of valepotriates isolated from Valeriana
glechomifolia on rat P-type ATPases. Planta Med. 2011 Oct;77(15):1702-6. doi:
10.1055/s-0030-1271084. Epub 2011 May 12. Erratum in: Planta Med. 2011
Oct;77(15):E14. Quintas, Luis E M [corrected to Quintas, Luis Eduardo M]. PMID:
21567360.

4: Müller LG, de Andrade Salles L, Sakamoto S, Stein AC, Cargnin ST, Cassel E,
Vargas RF, Rates SM, von Poser GL. Effect of storage time and conditions on the
diene valepotriates content of the extract of Valeriana glechomifolia obtained
by supercritical carbon dioxide. Phytochem Anal. 2012 May-Jun;23(3):222-7. doi:
10.1002/pca.1346. Epub 2011 Sep 23. PMID: 21953720.

5: Erdoğan M, Aru B, Yılmaz ŞT, Yeşilada E, Yanıkkaya-Demirel G, Kırmızıbekmez
H. Secondary metabolites from the underground parts of Valeriana sisymbriifolia
Vahl. and their in vitro cytotoxic activities. Phytochemistry. 2023
Apr;208:113590. doi: 10.1016/j.phytochem.2023.113590. Epub 2023 Jan 22. PMID:
36696936.