AT-090

    WARNING: This product is for research use only, not for human or veterinary use.

Hodoodo CAT#: H124678

CAS#: 2099681-59-9

Description: AT-090 is a novel potent, selective nociceptin/orphanin FQ receptor (NOP receptor) agonist

Chemical Structure

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AT-090
CAS# 2099681-59-9
Instruction

Theoretical Analysis

Hodoodo Cat#: H124678
Name: AT-090
CAS#: 2099681-59-9
Chemical Formula: C22H30N2O2
Exact Mass: 354.23
Molecular Weight: 354.490
Elemental Analysis: C, 74.54; H, 8.53; N, 7.90; O, 9.03

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @hodoodo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: AT090; AT 090; AT-090

IUPAC/Chemical Name: 1-(1-((1s,4s)-4-iso-propylcyclohexyl)piperidin-4-yl)indoline-2,3-dione

InChi Key: RCRPVEANWGMGSQ-CALCHBBNSA-N

InChi Code: InChI=1S/C22H30N2O2/c1-15(2)16-7-9-17(10-8-16)23-13-11-18(12-14-23)24-20-6-4-3-5-19(20)21(25)22(24)26/h3-6,15-18H,7-14H2,1-2H3/t16-,17+

SMILES Code: O=C1N(C2CCN([C@H]3CC[C@@H](C(C)C)CC3)CC2)C4=C(C=CC=C4)C1=O

Appearance: To be determined

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 354.49 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Denys IB, Gao J, Sutphen JC, Zaveri NT, Kapusta DR. Cardiovascular and renal
effects of novel nonpeptide nociceptin opioid peptide receptor agonists. Br J
Pharmacol. 2022 Jan;179(2):287-300. doi: 10.1111/bph.15717. Epub 2021 Dec 12.
PMID: 34705263; PMCID: PMC8716424.

2: Ferrari F, Cerlesi MC, Malfacini D, Asth L, Gavioli EC, Journigan BV,
Kamakolanu UG, Meyer ME, Yasuda D, Polgar WE, Rizzi A, Guerrini R, Ruzza C,
Zaveri NT, Calo G. In vitro functional characterization of novel
nociceptin/orphanin FQ receptor agonists in recombinant and native preparations.
Eur J Pharmacol. 2016 Dec 15;793:1-13. doi: 10.1016/j.ejphar.2016.10.025. Epub
2016 Oct 22. PMID: 27780725; PMCID: PMC5555400.

3: Asth L, Ruzza C, Malfacini D, Medeiros I, Guerrini R, Zaveri NT, Gavioli EC,
Calo' G. Beta-arrestin 2 rather than G protein efficacy determines the
anxiolytic-versus antidepressant-like effects of nociceptin/orphanin FQ receptor
ligands. Neuropharmacology. 2016 Jun;105:434-442. doi:
10.1016/j.neuropharm.2016.02.003. Epub 2016 Feb 8. PMID: 26867504; PMCID:
PMC5567672.

4: Silva EF, Silva AI, Asth L, Souza LS, Zaveri NT, Guerrini R, Calo' G, Ruzza
C, Gavioli EC. Nociceptin/orphanin FQ receptor agonists increase aggressiveness
in the mouse resident-intruder test. Behav Brain Res. 2019 Jan 1;356:120-126.
doi: 10.1016/j.bbr.2018.08.019. Epub 2018 Aug 22. PMID: 30142397.

5: Asth L, Tiago PRF, Costa LRF, Holanda VAD, Pacifico S, Zaveri NT, Calo' G,
Ruzza C, Gavioli EC. Effects of non-peptide nociceptin/orphanin FQ receptor
ligands on methylphenidate-induced hyperactivity in mice: Implications for
bipolar disorders. Neuropeptides. 2020 Aug;82:102059. doi:
10.1016/j.npep.2020.102059. Epub 2020 Jun 15. PMID: 32600667.