Hydroxynorketamine, (2S,6S)-

    WARNING: This product is for research use only, not for human or veterinary use.

Hodoodo CAT#: H124671

CAS#: 95342-35-1

Description: Hydroxynorketamine, (2S,6S)- inhibits the induction of NMDA receptor

Chemical Structure

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Hydroxynorketamine, (2S,6S)-
CAS# 95342-35-1
Instruction

Theoretical Analysis

Hodoodo Cat#: H124671
Name: Hydroxynorketamine, (2S,6S)-
CAS#: 95342-35-1
Chemical Formula: C12H14ClNO2
Exact Mass: 239.07
Molecular Weight: 239.700
Elemental Analysis: C, 60.13; H, 5.89; Cl, 14.79; N, 5.84; O, 13.35

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @hodoodo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: V7MB1GM2IM; (2S,6S)-Hnk; (2S,6S)-Hydroxynorketamine; Hydroxynorketamine, (2S,6S)-; 95342-35-1

IUPAC/Chemical Name: 2-amino-2-(2-chlorophenyl)-6-hydroxycyclohexan-1-one

InChi Key: CFBVGSWSOJBYGC-UHFFFAOYSA-N

InChi Code: InChI=1S/C12H14ClNO2/c13-9-5-2-1-4-8(9)12(14)7-3-6-10(15)11(12)16/h1-2,4-5,10,15H,3,6-7,14H2

SMILES Code: C1CC(C(=O)C(C1)(C2=CC=CC=C2Cl)N)O

Appearance: To be determined

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 239.70 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Kang H, Park P, Han M, Tidball P, Georgiou J, Bortolotto ZA, Lodge D, Kaang
BK, Collingridge GL. (2S,6S)- and
(2R,6R)-hydroxynorketamine inhibit the induction of NMDA receptor-
dependent LTP at hippocampal CA1 synapses in mice. Brain Neurosci Adv. 2020 Sep
28;4:2398212820957847. doi: 10.1177/2398212820957847. PMID: 33088919; PMCID:
PMC7545754.

2: Lilius TO, Viisanen H, Jokinen V, Niemi M, Kalso EA, Rauhala PV. Interactions
of (2S,6S;2R,6R)-Hydroxynorketamine, a Secondary Metabolite of (R,S)-Ketamine,
with Morphine. Basic Clin Pharmacol Toxicol. 2018 May;122(5):481-488. doi:
10.1111/bcpt.12941. Epub 2017 Dec 27. PMID: 29171155.

3: Chen BK, Luna VM, LaGamma CT, Xu X, Deng SX, Suckow RF, Cooper TB, Shah A,
Brachman RA, Mendez-David I, David DJ, Gardier AM, Landry DW, Denny CA. Sex-
specific neurobiological actions of prophylactic (R,S)-ketamine,
(2R,6R)-hydroxynorketamine, and (2S,6S)-hydroxynorketamine.
Neuropsychopharmacology. 2020 Aug;45(9):1545-1556. doi:
10.1038/s41386-020-0714-z. Epub 2020 May 17. PMID: 32417852; PMCID: PMC7360766.