WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H124672
CAS#: 2414062-26-1
Description: This agent provided a noninvasive measure of adrenal function and steroid synthesis.
Hodoodo Cat#: H124672
Name: Norcholestenol fluoromethyl
CAS#: 2414062-26-1
Chemical Formula: C27H45FO
Exact Mass: 404.35
Molecular Weight: 404.650
Elemental Analysis: C, 80.14; H, 11.21; F, 4.69; O, 3.95
This product is not in stock, which may be available by custom synthesis.
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Synonym: Norcholestenol fluoromethyl; JR4U5E1Q6O; (F)Np-59; UNII-JR4U5E1Q6O; 2414062-26-1
IUPAC/Chemical Name: (3S,6R,8S,9S,13R,14S,17R)-6-(fluoromethyl)-13-methyl-17-((R)-6-methylheptan-2-yl)-2,3,4,6,7,8,9,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-ol
InChi Key: RPKBMZPQDSZBMF-YVJYXHLXSA-N
InChi Code: InChI=1S/C27H45FO/c1-17(2)6-5-7-18(3)25-10-11-26-24-14-19(16-28)23-15-20(29)8-9-21(23)22(24)12-13-27(25,26)4/h17-20,22,24-26,29H,5-16H2,1-4H3/t18-,19+,20+,22-,24-,25-,26+,27-/m1/s1
SMILES Code: C[C@H](CCCC(C)C)[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2C[C@H](C4=C3CC[C@@H](C4)O)CF)C
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 404.65 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Brooks AF, Winton WP, Stauff J, Arteaga J, Henderson B, Niedbala J, Scott
PJH, Viglianti BL. Development of Fluorinated NP-59: A Revival of Cholesterol
Use Imaging with PET. J Nucl Med. 2022 Dec;63(12):1949-1955. doi:
10.2967/jnumed.122.263864. Epub 2022 Apr 28. PMID: 35483964; PMCID: PMC9730927.
2: Vezzosi D, Tenenbaum F, Cazabat L, Tissier F, Bienvenu M, Carrasco CA, Laloi-
Michelin M, Barrande G, Lefebvre H, Hiéronimus S, Tabarin A, Bertagna X, Legmann
P, Vantyghem MC, Bertherat J. Hormonal, Radiological, NP-59 Scintigraphy, and
Pathological Correlations in Patients With Cushing's Syndrome Due to Primary
Pigmented Nodular Adrenocortical Disease (PPNAD). J Clin Endocrinol Metab. 2015
Nov;100(11):4332-8. doi: 10.1210/jc.2015-2174. Epub 2015 Sep 21. PMID: 26390100.