WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H124668
CAS#: 35620-67-8
Description: Pirdonium is an antihistamine agent. It is the hydrophilic Histamine H1 receptor antagonist.
Hodoodo Cat#: H124668
Name: Pirdonium bromide
CAS#: 35620-67-8
Chemical Formula: C22H30BrNO
Exact Mass: 403.15
Molecular Weight: 404.390
Elemental Analysis: C, 65.34; H, 7.48; Br, 19.76; N, 3.46; O, 3.96
This product is not in stock, which may be available by custom synthesis.
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Synonym: Pirdonium bromide; 35620-67-8; UNII-5123Q291S5; 5123Q291S5; Pirdonium bromide [INN]
IUPAC/Chemical Name: 1,1-dimethyl-2-((phenyl(p-tolyl)methoxy)methyl)piperidin-1-ium bromide
InChi Key: DJJOASJXEODSJF-UHFFFAOYSA-M
InChi Code: InChI=1S/C22H30NO.BrH/c1-18-12-14-20(15-13-18)22(19-9-5-4-6-10-19)24-17-21-11-7-8-16-23(21,2)3;/h4-6,9-10,12-15,21-22H,7-8,11,16-17H2,1-3H3;1H/q+1;/p-1
SMILES Code: CC1=CC=C(C=C1)C(C2=CC=CC=C2)OCC3CCCC[N+]3(C)C.[Br-]
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
| Biological target: | |
| In vitro activity: | |
| In vivo activity: |
The following data is based on the product molecular weight 404.39 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
1: Hishinuma S, Komazaki H, Tsukamoto H, Hatahara H, Fukui H, Shoji M.
Ca2+ -dependent down-regulation of human histamine H1
receptors in Chinese hamster ovary cells. J Neurochem. 2018 Jan;144(1):68-80.
doi: 10.1111/jnc.14245. Epub 2017 Nov 21. PMID: 29063596.
2: Hishinuma S, Komazaki H, Fukui H, Shoji M. Ubiquitin/proteasome-dependent
down-regulation following clathrin-mediated internalization of histamine
H1-receptors in Chinese hamster ovary cells. J Neurochem. 2010
May;113(4):990-1001. doi: 10.1111/j.1471-4159.2010.06669.x. Epub 2010 Mar 4.
PMID: 20236220.
3: Hishinuma S, Young JM. Characteristics of the binding of [3H]-mepyramine to
intact human U373 MG astrocytoma cells: evidence for histamine-induced
H1-receptor internalisation. Br J Pharmacol. 1995 Nov;116(6):2715-23. doi:
10.1111/j.1476-5381.1995.tb17232.x. PMID: 8590995; PMCID: PMC1909113.
4: Self TJ, Oakley SM, Hill SJ. Clathrin-independent internalization of the
human histamine H1-receptor in CHO-K1 cells. Br J Pharmacol. 2005
Oct;146(4):612-24. doi: 10.1038/sj.bjp.0706337. PMID: 16086035; PMCID:
PMC1751180.
5: Hishinuma S, Naiki A, Tsuga H, Young JM. Ca2+/calmodulin-mediated regulation
of agonist-induced sequestration of Gq protein-coupled histamine H1 receptors in
human U373 MG astrocytoma cells. J Neurochem. 1998 Dec;71(6):2626-33. doi:
10.1046/j.1471-4159.1998.71062626.x. PMID: 9832164.
