WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H124684
CAS#: 1158-80-1
Description: Spirazidine is a dispirotripiperazine (DSTP), which is a spirocyclic quaternary ammonium salts composed of piperazine or homopiperazine rings linked by shared nitrogen atoms. The DSTP ring system is commonly flanked by terminal N-acyl or N-heteroaryl groups, which can be varied to affect their physicochemical properties. Spirazidine displayed a wide spectrum of anticancer activity and relatively low toxicity, garnering interest from a number of groups as a potential drug Lead., which is a spirocyclic quaternary ammonium salts composed of piperazine or homopiperazine rings linked by shared nitrogen atoms. The DSTP ring system is commonly flanked by terminal N-acyl or N-heteroaryl groups, which can be varied to affect their physicochemical properties. Spirazidine displayed a wide spectrum of anticancer activity and relatively low toxicity, garnering interest from a number of groups as a potential drug Lead.
Hodoodo Cat#: H124684
Name: Spirazidine
CAS#: 1158-80-1
Chemical Formula: C16H32Cl4N4
Exact Mass: 420.14
Molecular Weight: 422.260
Elemental Analysis: C, 45.51; H, 7.64; Cl, 33.58; N, 13.27
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Synonym: Spirazidine; Spirasidin; Spirazidin
IUPAC/Chemical Name: 3,12-bis(2-chloroethyl)-3,6,9,12-tetraazadispiro[5.2.59.26]hexadecane-6,9-diium chloride
InChi Key: OYWCUEAJSZQIEE-UHFFFAOYSA-L
InChi Code: InChI=1S/C16H32Cl2N4.2ClH/c17-1-3-19-5-9-21(10-6-19)13-15-22(16-14-21)11-7-20(4-2-18)8-12-22;;/h1-16H2;2*1H/q+2;;/p-2
SMILES Code: C1C[N+]2(CCN1CCCl)CC[N+]3(CCN(CC3)CCCl)CC2.[Cl-].[Cl-]
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
| Biological target: | |
| In vitro activity: | |
| In vivo activity: |
The following data is based on the product molecular weight 422.26 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
1: Ado VA. Podavlenie allergicheskikh reaktsiĭ nemedlennogo tipa spirazidinom
[Suppression of allergic reaction of immediate type by spirazidine]. Farmakol
Toksikol. 1969 Sep-Oct;32(5):592-3. Russian. PMID: 5364679.
2: Ado VA, Podkolzin AA, Vermel' AE. Izuchenie immunodepressivnykh svoĭstv
novogo tsitostatika beta-khlorétilaminovogo riaa-spirazidina [Immunosuppressive
properties of a new cytostatic agent of beta-chloroethylene series,
spirazidine]. Sov Med. 1969 Oct;32(10):31-4. Russian. PMID: 5382731.
3: Beslekoev TI, Podkolzin AA, Ado VA. O podavlenii allergicheskikh reaktsiĭ
zamedlennogo tipa spirazidinom [On the inhibition of the delayed-type allergic
reactions by spirazidine]. Farmakol Toksikol. 1968 Jul-Aug;31(4):441-4. Russian.
PMID: 5698135.
