WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H124688
CAS#: 81792-35-0
Description: Teopranitol, a coronary vasodilator, was studied for the treatment of the acute myocardial ischemia.
Hodoodo Cat#: H124688
Name: Teopranitol
CAS#: 81792-35-0
Chemical Formula: C16H22N6O7
Exact Mass: 410.15
Molecular Weight: 410.390
Elemental Analysis: C, 46.83; H, 5.40; N, 20.48; O, 27.29
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Synonym: Teopranitol; 81792-35-0; Teopranitolum; UNII-631R1KON85; 631R1KON85
IUPAC/Chemical Name: [(3S,3aR,6S,6aS)-3-[3-(1,3-dimethyl-2,6-dioxopurin-7-yl)propylamino]-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan-6-yl] nitrate
InChi Key: XTEGRRHNMFDROI-YRRQLQLVSA-N
InChi Code: InChI=1S/C16H22N6O7/c1-19-14-11(15(23)20(2)16(19)24)21(8-18-14)5-3-4-17-9-6-27-13-10(29-22(25)26)7-28-12(9)13/h8-10,12-13,17H,3-7H2,1-2H3/t9-,10-,12+,13+/m0/s1
SMILES Code: O=[N+]([O-])O[C@H]1CO[C@@]2([H])[C@]1([H])OC[C@@H]2NCCCN3C=NC(N(C)C(N4C)=O)=C3C4=O
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 410.39 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Thiemermann C, Smith EF 3rd, Schrör K. Successful treatment of acute
myocardial ischaemia with teopranitol--a novel organic nitrate. Eur Heart J.
1986 May;7(5):418-24. doi: 10.1093/oxfordjournals.eurheartj.a062083. PMID:
3732290.
2: Darius H, Weiss P, Schrör K. Stereospecific stimulation of coronary vascular
PGI2 by organic nitrates--studies with the new compound teopranitol (KC-046).
Biomed Biochim Acta. 1984;43(8-9):S269-72. PMID: 6393969.
3: Engberding R, Tschakert H, Bender F, Rübe W. Anderungen szintigraphisch
bestimmter regionaler Blutvolumina bei Koronarkranken unter dem Einfluss der
neuen Substanz Teopranitol [Changes in scintigraphically determined regional
blood volume in coronary patients treated with the new substance teopranitol]. Z
Kardiol. 1984 Jun;73(6):370-3. German. PMID: 6475177.
4: Pohl U, Busse R. Endothelium-derived relaxant factor inhibits effects of
nitrocompounds in isolated arteries. Am J Physiol. 1987 Feb;252(2 Pt 2):H307-13.
doi: 10.1152/ajpheart.1987.252.2.H307. PMID: 3492925.
5: Schrör K, Ahland B, Weiss P, König E. Stimulation of coronary vascular PGI2
by organic nitrates. Eur Heart J. 1988 Jan;9 Suppl A:25-32. doi:
10.1093/eurheartj/9.suppl_a.25. PMID: 3137069.
6: Schrör K, Weiss P, Löbel P, Darius H, Latta G. Organische Nitrate und
Prostaglandine im kardiovaskulären System [Organic nitrates and prostaglandins
in the cardiovascular system]. Z Kardiol. 1986;75 Suppl 3:30-4. German. PMID:
3541416.