Teopranitol

    WARNING: This product is for research use only, not for human or veterinary use.

Hodoodo CAT#: H124688

CAS#: 81792-35-0

Description: Teopranitol, a coronary vasodilator, was studied for the treatment of the acute myocardial ischemia.


Chemical Structure

img
Teopranitol
CAS# 81792-35-0

Theoretical Analysis

Hodoodo Cat#: H124688
Name: Teopranitol
CAS#: 81792-35-0
Chemical Formula: C16H22N6O7
Exact Mass: 410.15
Molecular Weight: 410.390
Elemental Analysis: C, 46.83; H, 5.40; N, 20.48; O, 27.29

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @hodoodo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: Teopranitol; 81792-35-0; Teopranitolum; UNII-631R1KON85; 631R1KON85

IUPAC/Chemical Name: [(3S,3aR,6S,6aS)-3-[3-(1,3-dimethyl-2,6-dioxopurin-7-yl)propylamino]-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan-6-yl] nitrate

InChi Key: XTEGRRHNMFDROI-YRRQLQLVSA-N

InChi Code: InChI=1S/C16H22N6O7/c1-19-14-11(15(23)20(2)16(19)24)21(8-18-14)5-3-4-17-9-6-27-13-10(29-22(25)26)7-28-12(9)13/h8-10,12-13,17H,3-7H2,1-2H3/t9-,10-,12+,13+/m0/s1

SMILES Code: O=[N+]([O-])O[C@H]1CO[C@@]2([H])[C@]1([H])OC[C@@H]2NCCCN3C=NC(N(C)C(N4C)=O)=C3C4=O

Appearance: To be determined

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 410.39 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

1: Thiemermann C, Smith EF 3rd, Schrör K. Successful treatment of acute
myocardial ischaemia with teopranitol--a novel organic nitrate. Eur Heart J.
1986 May;7(5):418-24. doi: 10.1093/oxfordjournals.eurheartj.a062083. PMID:
3732290.

2: Darius H, Weiss P, Schrör K. Stereospecific stimulation of coronary vascular
PGI2 by organic nitrates--studies with the new compound teopranitol (KC-046).
Biomed Biochim Acta. 1984;43(8-9):S269-72. PMID: 6393969.

3: Engberding R, Tschakert H, Bender F, Rübe W. Anderungen szintigraphisch
bestimmter regionaler Blutvolumina bei Koronarkranken unter dem Einfluss der
neuen Substanz Teopranitol [Changes in scintigraphically determined regional
blood volume in coronary patients treated with the new substance teopranitol]. Z
Kardiol. 1984 Jun;73(6):370-3. German. PMID: 6475177.

4: Pohl U, Busse R. Endothelium-derived relaxant factor inhibits effects of
nitrocompounds in isolated arteries. Am J Physiol. 1987 Feb;252(2 Pt 2):H307-13.
doi: 10.1152/ajpheart.1987.252.2.H307. PMID: 3492925.

5: Schrör K, Ahland B, Weiss P, König E. Stimulation of coronary vascular PGI2
by organic nitrates. Eur Heart J. 1988 Jan;9 Suppl A:25-32. doi:
10.1093/eurheartj/9.suppl_a.25. PMID: 3137069.

6: Schrör K, Weiss P, Löbel P, Darius H, Latta G. Organische Nitrate und
Prostaglandine im kardiovaskulären System [Organic nitrates and prostaglandins
in the cardiovascular system]. Z Kardiol. 1986;75 Suppl 3:30-4. German. PMID:
3541416.