WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H124682
CAS#: N/A
Description: YPD-29B is a PD-1/PD-L1small-moleculeinhibitor.
Hodoodo Cat#: H124682
Name: YPD-29B
CAS#: N/A
Chemical Formula: C30H31BrN2O5
Exact Mass: 578.14
Molecular Weight: 579.490
Elemental Analysis: C, 62.18; H, 5.39; Br, 13.79; N, 4.83; O, 13.80
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Synonym: 78V6PF4YBX; YPD-29B; YPD29B; YPD 29B
IUPAC/Chemical Name: ((4-((2-bromo-[1,1'-biphenyl]-3-yl)methoxy)-5-methyl-2-(pyridin-3-ylmethoxy)cyclohexa-2,4-dien-1-yl)methyl)serine
InChi Key: ZMRIYGHBGFFYKQ-UHFFFAOYSA-N
InChi Code: InChI=1S/C30H31BrN2O5/c1-20-13-24(16-33-26(17-34)30(35)36)28(37-18-21-7-6-12-32-15-21)14-27(20)38-19-23-10-5-11-25(29(23)31)22-8-3-2-4-9-22/h2-12,14-15,24,26,33-34H,13,16-19H2,1H3,(H,35,36)
SMILES Code: CC1=C(OCC2=C(Br)C(C3=CC=CC=C3)=CC=C2)C=C(OCC4=CN=CC=C4)C(CNC(C(O)=O)CO)C1
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
| Biological target: | |
| In vitro activity: | |
| In vivo activity: |
The following data is based on the product molecular weight 579.49 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
1: Lai F, Ji M, Huang L, Wang Y, Xue N, Du T, Dong K, Yao X, Jin J, Feng Z, Chen
X. YPD-30, a prodrug of YPD-29B, is an oral small-molecule inhibitor targeting
PD-L1 for the treatment of human cancer. Acta Pharm Sin B. 2022
Jun;12(6):2845-2858. doi: 10.1016/j.apsb.2022.02.031. Epub 2022 Mar 4. Erratum
in: Acta Pharm Sin B. 2023 Jul;13(7):3178-3179. PMID: 35755282; PMCID:
PMC9214057.
2: Jiang J, Zou X, Liu Y, Liu X, Dong K, Yao X, Feng Z, Chen X, Sheng L, Li Y.
Simultaneous Determination of a Novel PD-L1 Inhibitor, IMMH-010, and Its Active
Metabolite, YPD-29B, in Rat Biological Matrices by Polarity-Switching Liquid
Chromatography-Tandem Mass Spectrometry: Application to ADME Studies. Front
Pharmacol. 2021 Jun 21;12:677120. doi: 10.3389/fphar.2021.677120. PMID:
34234673; PMCID: PMC8256334.
3: Lai F, Ji M, Huang L, Wang Y, Xue N, Du T, Dong K, Yao X, Jin J, Feng Z, Chen
X. Erratum: Author correction to "YPD-30, a prodrug of YPD-29B, is an oral
small-molecule inhibitor targeting PD-L1 for the treatment of human cancer"
[Acta Pharmaceutica Sinica B 12 (2022) 2845-2858]. Acta Pharm Sin B. 2023
Jul;13(7):3178-3179. doi: 10.1016/j.apsb.2023.05.003. Epub 2023 May 9. Erratum
for: Acta Pharm Sin B. 2022 Jun;12(6):2845-2858. PMID: 37521865; PMCID:
PMC10372818.
4: Wang Y, Liu X, Zou X, Wang S, Luo L, Liu Y, Dong K, Yao X, Li Y, Chen X,
Sheng L. Metabolism and Interspecies Variation of IMMH-010, a Programmed Cell
Death Ligand 1 Inhibitor Prodrug. Pharmaceutics. 2021 Apr 21;13(5):598. doi:
10.3390/pharmaceutics13050598. PMID: 33919384; PMCID: PMC8143347.
