WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H124752
CAS#: N/A
Description: mCMY020 is a potent, covalent inhibitor of TEAD transcriptional activity that occupies a conserved, central palmitoylation site on TEADs.
Hodoodo Cat#: H124752
Name: mCMY020
CAS#: N/A
Chemical Formula: C21H21FN4O
Exact Mass: 364.17
Molecular Weight: 364.420
Elemental Analysis: C, 69.21; H, 5.81; F, 5.21; N, 15.37; O, 4.39
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Synonym: mCMY020; mCMY 020; mCMY-020
IUPAC/Chemical Name: N-(5-(4-cyclohexylphenyl)pyrazolo[1,5-a]pyrimidin-3-yl)-2-fluoroacrylamide
InChi Key: ABFPVHJLBFDSGS-UHFFFAOYSA-N
InChi Code: InChI=1S/C21H21FN4O/c1-14(22)21(27)25-19-13-23-26-12-11-18(24-20(19)26)17-9-7-16(8-10-17)15-5-3-2-4-6-15/h7-13,15H,1-6H2,(H,25,27)
SMILES Code: FC(C(NC(C=N1)=C(N1C=C2)N=C2C(C=C3)=CC=C3C4CCCCC4)=O)=C
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 364.42 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
https://pubs.rsc.org/en/content/articlehtml/2023/cb/d3cb00089c
A covalent inhibitor of the YAP–TEAD transcriptional complex identified by high-throughput screening