ML171

    WARNING: This product is for research use only, not for human or veterinary use.

Hodoodo CAT#: H124754

CAS#: 6631-94-3

Description: ML-171 is a NOX inhibitor.

Chemical Structure

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ML171
CAS# 6631-94-3
Instruction

Theoretical Analysis

Hodoodo Cat#: H124754
Name: ML171
CAS#: 6631-94-3
Chemical Formula: C14H11NOS
Exact Mass: 241.06
Molecular Weight: 241.310
Elemental Analysis: C, 69.68; H, 4.59; N, 5.80; O, 6.63; S, 13.29

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @hodoodo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: ML171; ML 171; ML-171; 2-Acetylphenothiazine; 6631-94-3; 1-(10H-Phenothiazin-2-yl)ethanone; ML171; Ethanone, 1-(10H-phenothiazin-2-yl)-

IUPAC/Chemical Name: 1-(10H-phenothiazin-2-yl)ethanone

InChi Key: JWGBOHJGWOPYCL-UHFFFAOYSA-N

InChi Code: InChI=1S/C14H11NOS/c1-9(16)10-6-7-14-12(8-10)15-11-4-2-3-5-13(11)17-14/h2-8,15H,1H3

SMILES Code: CC(C(C=C1N2)=CC=C1SC3=C2C=CC=C3)=O

Appearance: To be determined

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 241.31 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Oh SH, Ahn JS, Oh EJ, Kim YJ, Yook JM, Lim JH, Jung HY, Choi JY, Kim CD, Park
SH, Kim YL, Cho JH. Single-Dose Toxicity Study on ML171, a Selective NOX1
Inhibitor, in Mice. Biomed Res Int. 2021 May 30;2021:5515478. doi:
10.1155/2021/5515478. PMID: 34195263; PMCID: PMC8181097.

2: Kumar S, Singh AK, Vinayak M. ML171, a specific inhibitor of NOX1 attenuates
formalin induced nociceptive sensitization by inhibition of ROS mediated ERK1/2
signaling. Neurochem Int. 2019 Oct;129:104466. doi:
10.1016/j.neuint.2019.104466. Epub 2019 May 23. PMID: 31129114.

3: da Silva BTA, Peloi KE, Ximenes VF, Nakamura CV, de Oliveira Silva
Lautenschlager S. 2-acetylphenothiazine protects L929 fibroblasts against UVB-
induced oxidative damage. J Photochem Photobiol B. 2021 Mar;216:112130. doi:
10.1016/j.jphotobiol.2021.112130. Epub 2021 Jan 23. PMID: 33561688.