WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H526862
CAS#: 115607-61-9
Description: SKF-96067, also known as SK&F-96067, is a reversible, lumenally acting inhibitor of the gastric (H+ + K+)-ATPase. At pH 7.0, SK&F 96067 inhibited K(+)-stimulated ATPase activity competitively with respect to the activating cation K+, with a Ki value of 0.39 +/- 0.05 microM. Under comparable conditions, SK&F 96067 was 32 times more potent as an inhibitor of the gastric (H+ + K+)-ATPase relative to the closely related (Na+ + K+)-ATPase.
Hodoodo Cat#: H526862
Name: SKF-96067
CAS#: 115607-61-9
Chemical Formula: C21H22N2O2
Exact Mass: 334.17
Molecular Weight: 334.419
Elemental Analysis: C, 75.42; H, 6.63; N, 8.38; O, 9.57
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Synonym: SKF-96067; SKF 96067; SKF96067; SK&F-96067; SK&F 96067; SK&F96067.
IUPAC/Chemical Name: 3-butyryl-4-(2-methylphenylamino)-8-methoxyquinoline
InChi Key: MAVJDLHBPIXVJL-UHFFFAOYSA-N
InChi Code: InChI=1S/C21H22N2O2/c1-4-8-18(24)16-13-22-21-15(10-7-12-19(21)25-3)20(16)23-17-11-6-5-9-14(17)2/h5-7,9-13H,4,8H2,1-3H3,(H,22,23)
SMILES Code: COC1=C2N=CC(C(CCC)=O)=C(NC3=CC=CC=C3C)C2=CC=C1
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 334.42 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Rhoden KJ, Tallini G, Douglas JS. H+-K+ ATPase inhibitors cause relaxation of
guinea pig and human airway smooth muscle in vitro. J Pharmacol Exp Ther. 1996
Mar;276(3):897-903. PubMed PMID: 8786567.
2: Parsons ME, Rushant B, Rasmussen TC, Leach C, Ife RJ, Postius S, Pope AJ.
Properties of the reversible, K(+)-competitive inhibitor of the gastric
(H+/K+)-ATPase, SK&F 97574. II. Pharmacological properties. Biochem Pharmacol.
1995 Nov 9;50(10):1551-6. PubMed PMID: 7503756.
3: Sarges R, Gallagher A, Chambers TJ, Yeh LA. Inhibition of bone resorption by
H+/K(+)-ATPase inhibitors. J Med Chem. 1993 Sep 17;36(19):2828-30. PubMed PMID:
8410997.
4: Moore TD, Metcalf AC, Swagzdis JE, Doyle E. High-performance liquid
chromatographic determination of concentrations of the reversible H+/K+ ATPase
inhibitor SK&F 97574 in plasma. J Chromatogr. 1993 Sep 8;619(1):172-6. PubMed
PMID: 8245159.
5: Pope AJ, Parsons ME. Reversible inhibitors of the gastric H+/K(+)-transporting
ATPase: a new class of anti-secretory agent. Trends Pharmacol Sci. 1993
Sep;14(9):323-5. Review. PubMed PMID: 8249153.
6: Keeling DJ, Malcolm RC, Laing SM, Ife RJ, Leach CA. SK&F 96067 is a
reversible, lumenally acting inhibitor of the gastric (H+ + K+)-ATPase. Biochem
Pharmacol. 1991 Jun 21;42(1):123-30. PubMed PMID: 1648919.