WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H124800
CAS#: 1660963-66-5
Description: Olafertinib maleate is an orally available third-generation and selective inhibitor of certain epidermal growth factor receptor (EGFR) activating mutations, including the resistance mutation T790M, with potential antineoplastic activity. Activating mutations in the tyrosine kinase domain of EGFR are found in approximately 20% of patients with
Hodoodo Cat#: H124800
Name: Olafertinib maleate
CAS#: 1660963-66-5
Chemical Formula: C33H32F2N6O6
Exact Mass: 646.24
Molecular Weight: 646.650
Elemental Analysis: C, 61.29; H, 4.99; F, 5.88; N, 13.00; O, 14.84
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Synonym: Olafertinib maleate; DQD03HG3J2; UNII-DQD03HG3J2; 1660963-66-5
IUPAC/Chemical Name: N-(3-(2-((2,3-difluoro-4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide fumarate
InChi Key: DHGXGXONULYUSQ-WLHGVMLRSA-N
InChi Code: InChI=1S/C29H28F2N6O2.C4H4O4/c1-2-25(39)33-21-7-3-5-19(17-21)22-8-4-6-20-18-32-29(35-28(20)22)34-23-9-10-24(27(31)26(23)30)37-13-11-36(12-14-37)15-16-38;5-3(6)1-2-4(7)8/h2-10,17-18,38H,1,11-16H2,(H,33,39)(H,32,34,35);1-2H,(H,5,6)(H,7,8)/b;2-1+
SMILES Code: C=CC(=O)NC1=CC=CC(=C1)C2=CC=CC3=CN=C(N=C32)NC4=C(C(=C(C=C4)N5CCN(CC5)CCO)F)F.C(=CC(=O)O)C(=O)O
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
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The following data is based on the product molecular weight 646.65 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
