WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H124808
CAS#: 2522933-44-2
Description: Dazdotuftide is a novel, small synthetic molecule. It is a peptide conjugate comprised of tuftsin and phosphorylcholine that are covalently attached. The phosphorylcholine (PPC) moiety is based on a sequence from helminths’ secretory molecules which has been shown to be responsible for their immunoregulatory functions. Dazdotuftide and its components demonstrated in various autoimmune animal models and in vitro test systems its inhibitory effect on TLR-4 (inhibition of NfKb cascade), NRP-1 (inhibition of VEGF 165), and ACE2
Hodoodo Cat#: H124808
Name: Dazdotuftide
CAS#: 2522933-44-2
Chemical Formula: C43H68N13O13P
Exact Mass: 1,005.48
Molecular Weight: 1,006.070
Elemental Analysis: C, 51.34; H, 6.81; N, 18.10; O, 20.67; P, 3.08
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Synonym: Dazdotuftide; TRS01; TRS-01; 8V4LO73JNW; 2522933-44-2
IUPAC/Chemical Name: 4-((5-(2-carboxy-2-(2-(5-((diaminomethylene)amino)-2-(1-(threonyllysyl)pyrrolidine-2-carboxamido)pentanamido)acetamido)ethyl)-2-hydroxyphenyl)diazenyl)phenyl (2-(trimethylammonio)ethyl) phosphate
InChi Key: VXUMKMXYKWBBDK-UHFFFAOYSA-N
InChi Code: InChI=1S/C43H68N13O13P/c1-26(57)37(45)40(62)52-31(9-5-6-18-44)41(63)55-20-8-11-34(55)39(61)51-30(10-7-19-48-43(46)47)38(60)49-25-36(59)50-33(42(64)65)24-27-12-17-35(58)32(23-27)54-53-28-13-15-29(16-14-28)69-70(66,67)68-22-21-56(2,3)4/h12-17,23,26,30-31,33-34,37,57H,5-11,18-22,24-25,44-45H2,1-4H3,(H10-,46,47,48,49,50,51,52,53,58,59,60,61,62,64,65,66,67)
SMILES Code: CC(C(C(=O)NC(CCCCN)C(=O)N1CCCC1C(=O)NC(CCCN=C(N)N)C(=O)NCC(=O)NC(CC2=CC(=C(C=C2)O)N=NC3=CC=C(C=C3)OP(=O)([O-])OCC[N+](C)(C)C)C(=O)O)N)O
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 1,006.07 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
Vofo BN, Chowers I. Suppressing Inflammation for the Treatment of Diabetic Retinopathy and Age-Related Macular Degeneration: Dazdotuftide as a Potential New Multitarget Therapeutic Candidate. Biomedicines. 2023 May 27;11(6):1562. doi: 10.3390/biomedicines11061562. PMID: 37371657; PMCID: PMC10295757.