WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H124832
CAS#: 30163-01-0
Description: Etoxadrol is an NMDA receptor antagonist. It exerts phencyclidine-like properties. Etoxadrol has anticonvulsant and anesthetic activity. Intravenous etoxadrol was clinically tested as an anesthetic.
Hodoodo Cat#: H124832
Name: Etoxadrol
CAS#: 30163-01-0
Chemical Formula: C16H23NO2
Exact Mass: 261.17
Molecular Weight: 261.370
Elemental Analysis: C, 73.53; H, 8.87; N, 5.36; O, 12.24
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Synonym: ETOXADROL; Etoxadrol, (+/-)-; Etoxadrol [INN]; RO44G6QT80; SIQ2UWR01K
IUPAC/Chemical Name: 2-(2-ethyl-2-phenyl-1,3-dioxolan-4-yl)piperidine
InChi Key: INOYCBNLWYEPSB-UHFFFAOYSA-N
InChi Code: InChI=1S/C16H23NO2/c1-2-16(13-8-4-3-5-9-13)18-12-15(19-16)14-10-6-7-11-17-14/h3-5,8-9,14-15,17H,2,6-7,10-12H2,1H3
SMILES Code: CCC1(OCC(O1)C2CCCCN2)C3=CC=CC=C3
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 261.37 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Sax M, Wünsch B. Relationships between the structure of dexoxadrol and
etoxadrol analogues and their NMDA receptor affinity. Curr Top Med Chem.
2006;6(7):723-32. doi: 10.2174/156802606776894483. PMID: 16719812.
2: Thurkauf A, Mattson MV, Huguenin PN, Rice KC, Jacobson AE. Etoxadrol-meta-
isothiocyanate: a potent, enantioselective, electrophilic affinity ligand for
the phencyclidine-binding site. FEBS Lett. 1988 Oct 10;238(2):369-74. doi:
10.1016/0014-5793(88)80514-3. PMID: 2901991.
3: Thurkauf A, Zenk PC, Balster RL, May EL, George C, Carroll FI, Mascarella SW,
Rice KC, Jacobson AE, Mattson MV. Synthesis, absolute configuration, and
molecular modeling study of etoxadrol, a potent phencyclidine-like agonist. J
Med Chem. 1988 Dec;31(12):2257-63. doi: 10.1021/jm00120a004. PMID: 2903930.
4: Hidalgo J, Dileo RM, Rikimaru MT, Guzman RJ, Thompson CR. Etoxadrol
(CL-1848C) a new dissociative anesthetic: studies in primates and other species.
Anesth Analg. 1971 Mar-Apr;50(2):231-9. PMID: 4994714.
5: Frederickson EL, Longnecker DE, Allen GW. Clinical investigation of a new
intravenous anesthetic--etoxadrol hydrochloride (CL-1848; U-37862A). Anesth
Analg. 1976 May-Jun;55(3):335-9. doi: 10.1213/00000539-197605000-00010. PMID:
5921.