WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H124834
CAS#: 1187432-35-4
Description: Fe-pe2I F-18 is a biomedical for lab use.
Hodoodo Cat#: H124834
Name: Fe-pe2I F-18
CAS#: 1187432-35-4
Chemical Formula: C20H25FINO2
Exact Mass: 457.09
Molecular Weight: 457.330
Elemental Analysis: C, 52.53; H, 5.51; F, 4.15; I, 27.75; N, 3.06; O, 7.00
This product is not in stock, which may be available by custom synthesis.
For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge).
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Synonym: HZ9FUP9E8I; (18F)Fe-pe2I; Fe-pe2I F-18; UNII-HZ9FUP9E8I; 1187432-35-4
IUPAC/Chemical Name: 2-fluoroethyl (E)-8-(3-iodoallyl)-3-(p-tolyl)-8-azabicyclo[3.2.1]octane-2-carboxylate
InChi Key: HOLJKTPTYVYXQS-WTDSWWLTSA-N
InChi Code: InChI=1S/C20H25FINO2/c1-14-3-5-15(6-4-14)17-13-16-7-8-18(23(16)11-2-10-22)19(17)20(24)25-12-9-21/h2-6,10,16-19H,7-9,11-13H2,1H3/b10-2+
SMILES Code: CC1=CC=C(C=C1)C2CC3CCC(C2C(=O)OCCF)N3CC=CI
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 457.33 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Varrone A, Tóth M, Steiger C, Takano A, Guilloteau D, Ichise M, Gulyás B,
Halldin C. Kinetic analysis and quantification of the dopamine transporter in
the nonhuman primate brain with 11C-PE2I and 18F-FE-PE2I. J Nucl Med. 2011
Jan;52(1):132-9. doi: 10.2967/jnumed.110.077651. PMID: 21189414.
2: Jakobson Mo S, Axelsson J, Stiernman LJ, Larsson A, Af Bjerkén S, Bäckström
D, Kellgren TG, Varrone A, Riklund K. VNTR polymorphism in the SLC6A3 gene does
not influence dopamine transporter availability measured by [18F]FE-PE2I PET or
[123I]FP-Cit SPECT. Nucl Med Commun. 2022 Mar 1;43(3):247-255. doi:
10.1097/MNM.0000000000001514. PMID: 34908018.
3: Sasaki T, Ito H, Kimura Y, Arakawa R, Takano H, Seki C, Kodaka F, Fujie S,
Takahata K, Nogami T, Suzuki M, Fujiwara H, Takahashi H, Nakao R, Fukumura T,
Varrone A, Halldin C, Nishikawa T, Suhara T. Quantification of dopamine
transporter in human brain using PET with 18F-FE-PE2I. J Nucl Med. 2012
Jul;53(7):1065-73. doi: 10.2967/jnumed.111.101626. Epub 2012 Jun 11. PMID:
22689927.
4: Jakobson Mo S, Axelsson J, Jonasson L, Larsson A, Ögren MJ, Ögren M, Varrone
A, Eriksson L, Bäckström D, Af Bjerkén S, Linder J, Riklund K. Dopamine
transporter imaging with [18F]FE-PE2I PET and [123I]FP-CIT
SPECT-a clinical comparison. EJNMMI Res. 2018 Nov 15;8(1):100. doi:
10.1186/s13550-018-0450-0. PMID: 30443684; PMCID: PMC6238014.